IJPR.2023.111

Type of Article:  Original Research

Volume 11; Issue 2 (April 2023)

Page No.: 4476-4482

DOI: https://dx.doi.org/10.16965/ijpr.2023.111

Is Liver Frailty and functional capacity associated with the severity of liver disease in patients awaiting Liver Transplantation? – A prospective Observational Study

Nirali S. Vakani *1, Harda H. Shah 2, Pranjal Modi 3, Vaibhav Sutariya 4, Bharat Tiwari 5.

ABSTRACT

1 Lecturer, IKDRC-ITS College of Physiotherapy, Civil Hospital Campus, Asarwa, Ahmedabad, Gujarat, India. ORCiD: 0000-0002-0040-5388

2 Senior Lecturer PT, PhD, IKDRC-ITS College of Physiotherapy, Civil Hospital Campus, Asarwa, Ahmedabad, Gujarat, India. ORCiD: 0000-0003-0994-2590

3 Head of Department of Urology and Abdominal Organ Transplantation and Vice-chancellor, Gujarat University of Transplantation Sciences, Civil hospital Campus, Asarwa, Ahmedabad, India. ORCiD: 0000-0002-7364-3002

4 Professor, Department of Abdominal Organ Transplantation Surgery, IKDRC-ITS Hospital, Civil Hospital Campus, Asarwa, Ahmedabad, Gujarat, India. 

5 I/C Principal and Senior Lecturer IKDRC-ITS College of Physiotherapy, Civil Hospital Campus, Asarwa, Ahmedabad, Gujarat, India. ORCiD: 0000-0001-7405-9548

Corresponding Author: Dr. Nirali Sunil Vakani, Lecturer, IKDRC–ITS College of Physiotherapy, Gujarat University of Transplantation Sciences, Civil Hospital Campus, Asarwa, Ahmedabad, Gujarat, India. E-Mail: nsvakani@gmail.com

ABSTRACT

Background: Liver is a major metabolic organ, interfering with the function of all organs and systems. So, the patients with severe liver disease may display wide manifestations of metabolic disorders, loss of muscle mass and function. Combination of these factors leads to decreased exercise tolerance and physical inactivity and it may be exaggerated with increasing severity of liver disease. The functional capacity could be severely affected due to multiple physiological derangements in these population. Hence, a liver transplant is the only cure for end stage liver disease. Currently only few literature are available that evaluated and described the status of frailty and functional capacity in these population. So we have tried to evaluate the same in Indian Population.

Methodology: After ethical committee approval and written inform consent, 85 cirrhotic patients who fulfilled the Inclusion and Exclusion criteria were included in the study. Disease specific history, Severity of Liver disease, Physical evaluation of frailty via Hand grip strength, Balance and time taken to do 5 chair stands , subjective functional capacity evaluation was done through Duke activity status Index (DASI).

Result: In 85 patients, the average Hand grip strength was 23.70 ± 10.60kg in males and 15.02± 5.08kg in females , average value of timed chair stands (TCS) was  18.18± 6.60 in males and 14.18± 8.65 in females , average balance score was 28.00 ±4.99 in males and 29.33± 2.58 in females and the average value of MELDNa was 22.2± 6.9.

Conclusion: When compared with normal Indian standard Liver cirrhotic patient, form of frailty and reduced functional capacity non predominant. That stressed emphasis on rehabilitation and nutritional counselling during waiting period for Transplantation.

KEY WORDS: Metabolic disorders, Non-predominant, Counselling.

 REFERENCES

[1]. Hall JE. Guyton and Hall textbook of medical physiology e-Book. Elsevier Health Sciences; 2010 JuLy19.
[2]. Sembulingam K, Sembulingam P. Essentials of medical physiology. JP Medical Ltd; 2012 Sep 30.
[3]. Jameson JL. Harrison’s principles of internal medicine. McGraw-Hill Education,; 2018.
[4]. Saeian K, Shaker R. Liver Disorders. 1st ed. 2017 Edition, Springer.
[5]. Tandon P, Low G, Mourtzakis M, Zenith L, Myers RP, Abraldes JG, Shaheen AA, Qamar H, Mansoor N, Carbonneau M, Ismond K. A model to identify sarcopenia in patients with cirrhosis. Clinical Gastroenterology and Hepatology. 2016 Oct 1;14(10):1473-80.
[6]. Lai JC, Sonnenday CJ, Tapper EB, Duarte‐Rojo A, Dunn MA, Bernal W, Carey . Frailty in liver transplantation: an expert opinion statement from the American Society of Transplantation Liver and Intestinal Community of Practice. American Journal of Transplantation. 2019 Jul; 19(7):1896-906.
[7]. Khan S, Nagarwala R, Shyam A, Sancheti P. Validation of Duke Activity Status Index questionnaire to determine functional capacity in young healthy nonexercising individuals. Physiotherapy-The Journal of Indian Association of Physiotherapists. 2019 Jan 1; 13(1):14.
[8]. Lai JC, Covinsky KE, McCulloch CE, Feng S. The liver frailty index improves mortality prediction of the subjective clinician assessment in patients with cirrhosis. The American journal of gastroenterology. 2018 Feb; 113(2):235.
[9]. Gaikwad NR, Gupta SJ, Samarth AR, Sankalecha TH. Handgrip dynamometry: a surrogate marker of malnutrition to predict the prognosis in alcoholic liver disease. Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology. 2016 Oct; 29(4):509.
[10]. Tai ML, Goh KL, Mohd-Taib SH, Rampal S, Mahadeva S. Anthropometric, biochemical and clinical assessment of malnutrition in Malaysian patients with advanced cirrhosis. Nutrition journal. 2010 Dec 1;9(1):27.
[11]. Laube R, Wang H, Park L, Heyman JK, Vidot H, Majumdar A, Strasser SI, Frailty in advanced liver disease. Liver International. 2018 Dec; 38(12):2117- 28.
[12]. Dhaliwal A, Williams FR, El-sheriff O, Armstrong MJ. Sarcopenia in Liver Transplantation: an Update. Current Hepatology Reports. 2020 Jun; 19(2):128-37.
[13]. Morkane CM, Kearney O, Bruce DA, Melikian CN, Martin DS. An outpatient hospital-based exercise training program for patients with cirrhotic liver disease awaiting transplantation: a feasibility trial. Transplantation. 2020 Jan 1; 104(1):97-103.

Cite this article: Nirali S. Vakani, Harda H. Shah, Pranjal Modi, Vaibhav Sutariya, Bharat Tiwari. Is Liver Frailty and functional capacity associated with severity of liver disease in patients awaiting Liver Transplantation? – A prospective Observational Study. Int J Physiother Res 2023;11(2):4476-4482. DOI: 10.16965/ijpr.2023.111