Type of Article:  Original Research

Volume 6; Issue 2 (April 2018)

Page No.: 2654-2659

DOI: https://dx.doi.org/10.16965/ijpr.2018.101


Mowaffak Mostafa Abd El Hamid 1, Noha Abd El Halim El Sawy 1 Abla Ahmed Abo Zeid 2,  Riham Abdelmaksoud Hamed Abdelmaksoud *1.

*1 Department of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Alexandria University, Egypt.

2 Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Egypt.

Address for Correspondence: Dr. Riham Abdelmaksoud Hamed Abdelmaksoud, Department of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Alexandria University, Egypt. E-Mail: reham.abdelmaksoud@yahoo.com


Osteoarthritis is characterized by cartilage degeneration or degradation of one or more joints. It is a common condition to affect synovial joints, the single most important cause of  locomotor disability and a major challenge to health care. Previous studies have suggested that diabetic patients are at higher risk of developing rheumatic disorders. Some have reported a correlation of osteoarthritis with longer diabetes mellitus duration and poor glycemic control. Furthermore, the presence of peripheral neuropathy in diabetes mellitus patients may increase the risk of aggressive forms of osteoarthritis. Some studies found that type 2 diabetes increases incidence of knee osteoarthritis and predicts the development of severe osteoarthritis independent of age and Body Mass Index. This paper gives data about prevalence and severity of osteoarthritis in diabetic type 2 patients.

Key words: Diabetes Mellitus, osteoarthritis, prevalence, peripheral neuropathy, poor glycemic control, longer diabetes mellitus duration.


  1. Oben J, Enonchong E, Kothari S. Phellodendron and Citrus extracts benefit joint health in osteoarthritis patients: a pilot, double-blind, placebo-controlled study. Nutr J 2009;8:38.
  2. Coggon D, Reading I, Croft P, McLaren M, Barrett D, Cooper C, et al. Knee osteoarthritis and obesity. Int J Obes Relat Metab Disord 2001;25: 622-7 as cited by Hunter D. Focusing osteoarthritis management on modifiable risk factors and future therapeutic prospects. Ther Adv Musculoskel Dis 2009;1(1):35:47.
  3. Moskowitz RW. Clinical and laboratory findings in osteoarthritis. In: Koopman WJ, editors. Arthritis and allied condition. 13th ed. Baltimore: Williams & Wilkins; 1997. P 1985-2011.
  4. O Reilly S, Doherty M. Signs, symptoms, and laboratory tests. In: Brandt KD, Doherty M, Lohmander LS,(eds). Osteoarthritis, 2nd ed. New York: Oxford University 2003 Press, pp.197-210.
  5. Hafez AR, Alenazi AM, Kachanathu SJ, Alroumi AM, Mohamed ES. Knee osteoarthritis: a review literature. Phys Med Rehabil Int 2014;1(5):8.
  6. Felson DT, Chaisson CE, Hill CL, Totterman SM, Gale ME, Skinner KM, et al . The association of bone marrow lesions with pain in knee osteoarthritis. Ann Intern Med. 2001;134:541-9.
  7. Gavin JR III, Alberti KGMM, Davidson MB. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997;20:1183-97.
  8. Shaw JE, Sicree RA , Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030 .Diabetes Res Clin Pract 2010;87(1):4-14.
  9. WHO Consultation Group. Definition, diagnosis and classification of diabetes mellitus and its complications. Report of a WHO Consultation, Part 1: diagnosis and classification of diabetes mellitus 2nded. Geneva: World Health Organization 1999;1-59.
  10. Rewers M, Norris JM, Eisenbarth GS, Erlich HA, Beaty B, Klingensmith G, et al. Beta-cell. autoantibodies in infants and toddlers without IDDM relatives: diabetes autoimmunity study in the young. J Autoimmun 1996;9:405-10.
  11. Holt PJL. Rheumatological manifestations of diabetes mellitus. Clin Rheum Dis 1981;7:723-46.
  12. Crisp AJ, Heathcoat JG. Connective tissue abnormalities in diabetes mellitus. J R Coll Physicians 1984;18:132-41.
  13. Gray RG, Gottlieb NL. Rheumatic disorders associated with diabetes mellitus: literature review. Semin Arthritis Rheum 1976;6:19-34.
  14. Stuemer T, Brenner H, Brenner RE, Gunther KP. Non- insulin dependant diabetes mellitus (NIDDM) and patterns of osteoarthritis. Scand J Rheumatol 2001;30(3):169-71.
  15. Bellamy N. WOMAC: a 20-year experiential review of a patient-centered self- reported health status questionnaire. J Rheumatol 2002;29:2473-6.
  16. McConnell S, Kolopack P, Davis AM. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC): a review of its utility and measurement.
  17. Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis 1957;16:494-502.
  18. Nieves-Plaza M, Castro-Santana LE, Front YM, Mayor AM,Vila LM. Association of hand or knee osteoarthritis with Diabetes Mellitus in a Population of hispancics From Puerto Rico. J Clin Rheumatol 2013;19:115-9.
  19. Hussien FY, Salow SA, Fadhil AS. Type 2 diabetes mellitus as a risk predictor of knee osteoarthritis: a case control series study among Iraqi people at Mosul city. Tikrit Medical Journal 2013;19(2):325-38.
  20. Louati K, Vidal C, Berenbaum F, Sellam J. Association between diabetes mellitus and osteoarthritis: systematic literature review and meta-analysis. RMD Open 2015;1:70-7.
  21. Cimmino MA, Cutolo M. Plasma glucose concentration in symptomatic osteoarthritis: a clinical and epidemiological survey. Clin Exp Rheumatol 1990;8:251-7.
  22. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001;414(6865):813-20.
  23. Verzijl N, DeGroot J, Ben ZC, Brau-Benjamin O, Maroudas A, Bank RA, et al. Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage a possible mechanism through which age is a risk factor for osteoarthritis. Arthritis Rheum 2002;46(1):114–23.
  24. Berenbaum F. Diabetes induced osteoarthrittis: From a new paradigm to a new phenotype. Ann Rheum Dis 2011;70(8):1354-6.
  25. Andersen H, Nielsen S, Mogensen CE, Jakobsen J. Muscle strength in type 2 diabetes. Diabetes 2004;53(6):1543-8.
  26. Schett G, Kleyer A, Perricone C, Sahinbegovic E, Iagnocco A, Zwerina J, et al. Dibetes is an independent predictor for severe osteoarthritis. Diabetes Care 2013;36:403-9.
  27. Cohen SE, Mahul O, Meir R, Rubinow A. Anserine bursitis and noninsulin dependent diabetes mellitus. J Rheumatol 1997;24:2162-5.
  28. Unlu Z, Ozmen B, Taethan S, Boyvoda S, Goktan C. Ultrasonographic evaluation of pes anserinus tendino-bursitis in patients with type 2 diabetes mellitus. J Rheumatol 2003;30:352-4.
  29. Jr MH, Kuromoto J. Anserine syndrome. Bras J Rheumatol 2010;50(3):313-27.
  30. Doyle DV, Dieppe PA, Scott J, Huskisson EC. An articular index for the assessment of osteoarthritis. Annals of the Rheumatic Diseases 1981;40:75-8.
  31. Willett TL, Kandel R, De Croos JNA, Avery NC, Grynpas MD. Enhanced levels of non-enzymatic glycation and pentosidine crosslinking in spontaneous osteoarthritis progression. Osteoarthrritis and Cartilage 2012;20(7):736-44.
  32. Sugiyama S, Miyata T, Ueda Y, Tanaka H, Maeda K, Kawashima S, et al. Plasma levels of pentosidine in diabetic patients: an advanced glycation end product. J Am Soc Nephrol 1998;9:1681-8.

Cite this article: Mowaffak Mostafa Abd El Hamid, Noha Abd El Halim El Sawy, Abla Ahmed Abo Zeid, Riham Abdelmaksoud Hamed Abdelmaksoud. PREVALENCE OF KNEE OSTEOARTHRITIS AMONG EGYPTIAN DIABETIC TYPE 2 PATIENTS. Int J Physiother Res 2018;6(2):2654-2659. DOI: 10.16965/ijpr.2018.101