Type of Article:  Original Research

Volume 5; Issue 2 (April 2017)

Page No.: 1902-1905

DOI: https://dx.doi.org/10.16965/ijpr.2016.178


Maitrey Pandya *1, Miral Damani 2.

*1 MPT, Neurophysiotherapist, Arogyam Hospital, Rajkot, Gujarat, India.

2 MPT, Lecturer, School Of physiotherapy RK University, Rajkot, Gujarat, India.

Address for Correspondence: Dr. Maitrey Pandya, MPT, Neurophysiotherapist, Arogyam Hospital, Rajkot, Gujrat, India.
E-Mail: maitrey.pandya07@rku.ac.in 


Background: Diabetes mellitus is characterized by inability of the body to metabolize glucose properly. The prevalence of diabetes is rapidly rising all over the globe at an alarming rate. IDDM and NIDDM shows effect on central nervous system, peripheral nervous system, autonomic nervous system, cardiovascular system and other physiological system. A common complication due to the IDDM and NIDDM includes peripheral neuropathy, retinopathy, nephropathy and vascular complication. Insulin and non-insulin dependent diabetes mellitus – both affect the peripheral nervous system depending on the duration of exposure and blood glucose level.

Materials and Methods: 120 healthy individuals with IDDM and NIDDM were included (screened with SF-36), with age limit between 25 to 60 years. Those individuals having a history of hospitalization in last 1 year, acute fever, present history of radiculopathy and open wound were excluded. Nerve conduction studies of common peroneal, tibial and sural nerves were examined in both groups. Distal Latency, NCV and CMAP/SNAP were taken as outcome measures.

Result and Discussion: Bio-statistical analysis has been done using Mann-Whitney test. Result suggest that long duration of exposure has significant (p<0.05) effect on Neurophysiological changes compare to short duration of exposure in IDDM and NIDDM. With longer exposure of diabetes, there is increase in latency, decrease in amplitude and NCV.

Conclusion: Long duration of exposure shows significant Neurophysiological changes compare to short duration of exposure in IDDM and NIDDM.

Key words: Insulin dependent diabetes mellitus (IDDM), Non-insulin dependent diabetes mellitus (NIDDM), Nerve conduction velocity (NCV).


  1. AL Kakrani, Gokhale, Karan Vohra et al. Clinical and Nerve Conduction Study Correlation in Patients of Diabetic Neuropathy. Journal of the association of physicians of India. .2014;62:24-7.
  2. Mohan, Sandeep, Deepa et al. Epidemiology of type 2 diabetes: Indian scenario. Indian Journal of medical research. 2007;125:217-30.
  3. Lindsay, Bone, Callander. Neurology and neurosurgery illustrated. 3rd 1997:525.
  4. Aspi and Sharukh Golwala.Medicine for students. 22nd 2009;437-44.
  5. Mamta, Abigail, Catherine et al. Peripheral Neuropathy in Adolescents and Young Adults With Type1and Type2 Diabetes From the search for Diabetes in Youth Follow-up Cohort. American diabetes association. 2013;36:3903-9.
  6. Callaghan, Little, Feldman et al. Enhanced glucose control for preventing and treating diabetic neuropathy (Review). The cohort collaboration.2012;6:1-55.
  7. Jun Kimura M. D. Electro diagnosis in Diseases of Nerve and Muscle. Principles and Practice. 3rd; 1987:653.
  8. Claus, Mustafa, Vogel et al. Assessment of diabetic neuropathy. Definition of norm and discrimination of abnormal nerve function. Muscle nerve 1993;16:757–768.
  9. Dyck, Karnes, Daube et al. Clinical and Neuro pathological criteria for the diagnosis and staging of diabetic polyneuropathy. Brain. 1985;108:861–880.
  10. Properties of cutaneous afferents in diabetic neuropathy. Brain. 1989;112:1359–1376.
  11. Niakan, Harati. Sympathetic skin response in diabetic peripheral neuropathy. Muscle nerve. 1988;11:261–264.
  12. Le Quesne, Fowler, Parkhouse. Peripheral neuropathy profile in various groups of diabetics. Journal of neurology neurosurgery and psychiatry. 1990;53:558–563.
  13. Halar, Graf, Halter et al. Diabetic neuropathy. A clinical, laboratory and electro diagnostic study. Archives of physical medicine and rehabilitation. 1982;63:298– 303.
  14. Conrad, Aschoff, Fischler M.neurophysiological changes in patients with long duration diabetes.J Neurology. 1975;210:151–159.
  15. Sultna, Begum, Hussain et al. Electrophysiological changes of motor nerves in patients with type 2 diabetes mellitus. Journal of armed forces medical college. 2009;5(2):14-17.
  16. Arindam, Santa, Premchandra. Prevalence of peripheral neuropathy in newly diagnosed type 2 diabetics. International Journal of diabetes in developing country. 2005;25:30-3.
  17. Major Sharmeen, Noorzahan, Ali et al. Electrophysiological changes of Sensory Nerves In Patients with Type-2 Diabetes Mellitus of Different Duration. BSMMU Journal. 2010;3(1):9-12.
  18. Vinik, Holland, Beua et al. Diabetic neuropathies.Diabetes care 1992;15(12):1926-1951.
  19. Diabetic neuropathy, influence of age, sex, metabolic control and duration of diabetes on motor conduction velocity. Neurology 1967;17:972-980.
  20. Valensi, Giroux, Seeboth et al. Diabetic peripheral neuropathy: effects of age, duration of diabetes, glycemic control and vascular factors. Journal of Diabetes and its Complication. 1997;11:27-34.
  21. Kuniman, Wilborn, Mc Cann, et al. Prevalence of diabetic complications in relation to risk factors. Diabetes 1986;35:1332-1339.

Cite this article: Maitrey Pandya, Miral Damani. NEUROPHYSIOLOGICAL CHANGES IN CONTEXT TO DURATION OF EXPOSURE IN INSULIN DEPENDENT AND NON INSULIN DEPENDENT DIABETES MELLITUS. Int J Physiother Res 2017;5(2):1902-1905. DOI: 10.16965/ijpr.2016.178