IJAR.2023.259

Type of Article:  Original Research

Volume 12; Issue 1 (March 2024)

Page No.: 8840-8848

DOI: https://dx.doi.org/10.16965/ijar.2023.259

Hardy-Weinberg Equilibrium Study of Some Morphogenetic Traits in a Nigerian Population

Jaiyeoba-Ojigho Jennifer Efe *1, Lilian Ebele Chris-Ozoko 1, Enaohwo Mamerhi Taniyohwo 1, Ubogu Joseph Aforkogene 1, Emmanuel Ikechukwu Okolie 2, Innocent Onyesom 3.

*1 Department of Human Anatomy, Faculty of Basic Medical Sciences, Delta State University, Abraka, Nigeria.

2 Department of Nursing and Midwifery, University of Central Lancashire, Preston, England.

3 Malaria Research Unit, Department of Biochemistry, Faculty of Basic Medical Sciences, Delta State University, Abraka, Nigeria.

ORCiD:

Jaiyeoba-Ojigho Jennifer Efe: 0000-0002-5921-0876

Lilian Ebele Chris-Ozoko:  0000-0001-8092-4382

Innocent Onyesom: 0000-0001-7095-7666

Ubogu Joseph Aforkogene: NA

Emmanuel Ikechukwu Okolie: 0000-0002-8510-2828

Emmanuel Ikechukwu Okolie: 0000-0002-8510-2828

Corresponding Author: Jaiyeoba-Ojigho Jennifer Efe, Department of Human Anatomy, Faculty of Basic Medical Sciences, Delta State University, Abraka, Nigeria. E-Mail: efemenaojigho@gmail.com

ABSTRACT 

Background: The Hardy-Weinberg (HW) equilibrium studies the distribution of allelic and genotypic frequencies within a population. It provides a mathematical benchmark for a population that is evolving and not evolving.

Aim: This study investigated six morphogenetic traits among families in a Nigerian population using the Hardy-Weinberg principle with the aim of evaluating if the population was in HW equilibrium.

Methodology:   A total of 45 families comprising a father, mother and at least one offspring were conveniently sampled in Ogbe- Ijoh district in Delta State, Nigeria. Earlobe attachment, Hand clasping, Hitchhiker’s thumb, Leg folding, Morton’s toe and Widow’s peak were studied for their allelic and genotypic frequencies. The Chi-square test was used to analyse the association between these traits and sex, and conformance to the Mendelian inheritance pattern was evaluated with a Mendelian Chi-square.  The Hardy-Weinberg equilibrium compared the allelic frequencies of parents with those of offspring.  

Results: Males had higher frequencies for attached earlobes, Morton’s toe and widow’s peak (35.1, 51.9, 49.4%), while the females showed a predominance for hitchhiker’s thumb, right hand clasping and leg folding (50,72.4,70.7%). There was no association between the traits and gender (p>0.05). From the Mendelian Chi-square, free earlobe, right-hand clasping, right leg folding, Morton’s toe (SBt), the recessive phenotype of hitchhiker’s thumb as well as widow’s peak were the dominant traits in the studied population (X2  < 3.841 ). The H-W equation revealed a deviation of the offspring’s genotype from those of the parents for earlobe, hand clasping, leg folding, Morton’s toe and widow’s peak (1:1:2 [1:1; 4]; 2: 1: 3 [1:1:2]; 3:1:3 [1:1:2]; 5: 1: 4 [6:1:5}; 5:1:4 [7: 1:5]). However, parental and offspring alleles were identical for hitchhiker’s thumb (5:1:5 [5:1: 5]). The homozygotes for both parents and offspring outnumbered the heterozygotes for all traits (295: 245; 156: 119).

Conclusion: The study showed that only the hitchhiker’s thumb was in HW equilibrium, suggesting that evolution may not occur at that locus.

Keywords:  Hardy-Weinberg equilibrium, Mendel, Traits, Nigeria, Population.

REFERENCES

[1]. Jankowska D, Milewski R, Cwalina U, Milewska AJ. Application of Hardy-Weinberg law in biomedical research. Studies in Logic, Grammar and Rhetoric. 2011; 25(38):7-27.
[2]. Milgroom MG. Population biology of plant pathogens: genetics, ecology, and evolution. St. Paul, MN: American Phytopathological Society. 2015.
[3]. Grünwald NJ, Everhart SE, Knaus BJ, Kamvar ZN. 2017. Best practices for population genetic analyses. Papers in Plant Pathology. 2017; 421.
https://doi.org/10.1094/PHYTO-12-16-0425-RVW
PMid:28513284
[4]. Shizhong XU. Quantitative genetics. Basic concepts of population Genetics. 2022; pp 25- 33.
https://doi.org/10.1007/978-3-030-83940-6_3
[5]. Ebeye OA, Chris-Ozoko LE, Ogeneovo P, Onoriode A. A study of some morphogenetic traits among the esan ethnic group of Nigeria. East Africa Medical Journal. 2014 Nov;91(11):420-2.
[6]. Aigbogun EO, Alabi AS, Didia BC, Ordu KS. Morton’s Toe: Prevalence and Inheritance Pattern among Nigerians. International Journal of Applied Basic and Medical Research. 2019 Apr-Jun;9(2):89-94.
https://doi.org/10.4103/ijabmr.IJABMR_128_18
PMid:31041171 PMCid:PMC6477964
[7]. Asita AO, Ntsane K, Taole MM. Occurrence and Distribution of 16 Human Morphogenetic Traits in the Maseru District of Lesotho. British journal of healthcare and medical research . 2022; 9(5):403-25
https://doi.org/10.14738/jbemi.95.13335
[8]. Ordu KS, Aigbogun EO, Nwankwo JC. Evaluation of nose shape as a Mendelian inherited trait in the determination of parentage among Nigerians in Port Harcourt. Journal of Experimental and Clinical Anatomists. 2016;15:9 13
https://doi.org/10.4103/1596-2393.190824
[9]. Beckman, L., Böök, JA. Distribution and inheritance of mid-digital hair in Sweden. Hereditas, 1959; 45 (2-3)
https://doi.org/10.1111/j.1601-5223.1959.tb03052.x
[10]. Hugo P, Eliaman Q, John K. History of evolution and its concept. 6th ed, New York City. 2003 55-66.
[11]. Ordu KS Didia BC, Egbunefu N. Inheritance pattern of earlobe attachment amongst Nigerians. Greener journal of human physiology and anatomy. 2014;2;1‑7
https://doi.org/10.15580/GJHPA.2014.1.012214054
[12]. Kaplan AR. Genetics of relative toe lengths. Acta Geneticae Medicae Gemellolgaie (Roma) 1964;13:295-304.
https://doi.org/10.1017/S1120962300015602
PMid:14198926
[13]. Lutze FE. The inheritance of the manner of clasping the hands. The American Naturalist; 1908; 42:195-196.
https://doi.org/10.1086/278920
[14]. Freire-Maia, A. Twin data on hand clasping: a reanalysis. Acta Genetica et Statistica Medica. 1961; 10: 207-211.
https://doi.org/10.1017/S112096230001708X
PMid:13701700
[15]. Pons, J. Hand clasping (Spanish data). Annals of Human Genetics. 1961; 25: 141-144
https://doi.org/10.1111/j.1469-1809.1961.tb01511.x
PMid:14487797
[16]. Reiss M. Leg-crossing: incidence and inheritance. Neuropsychologia. 1994 Jun;32(6):747-50.
https://doi.org/10.1016/0028-3932(94)90034-5
PMid:8084429
[17]. Anibor E. Okolugbo N. Emmanuel I. Charity and Odiete E.(2021). Pattern of earlobe attachment among the Ika ethnic group in Delta State, Nigeria. GSC Advanced Research and Reviews, 7(3): 054-057
https://doi.org/10.30574/gscarr.2021.7.3.0116
[18]. John NP, Joy O, Gospel CD, Amaka AO, Chioma AO. Pattern of Earlobes Attachment among the Idoma People of Benue State, Nigeria. Scholars Journal of Applied Medical Sciences, 2022 Dec 10(12): 2419.
https://doi.org/10.36347/sjams.2022.v10i12.057
[19]. John Nwolim Paul et al. Descriptive Study of the Idoma People and Pattern of Hand Clasping. Saudi Journal of Medicine. 2023; 8(4): 140-144.
https://doi.org/10.36348/sjm.2023.v08i04.002
[20]. Onyije M, Oyinbo CA, Waritimi EG.The prevalence and comparison of bent little finger and Hitchhiker’s thumb in South-South Nigeria. European Journal of Applied Sciences.2012; 4 (4): 157-159.

Cite this article: Jaiyeoba-Ojigho Jennifer Efe, Lilian Ebele Chris-Ozoko, Enaohwo Mamerhi Taniyohwo, Ubogu Joseph Aforkogene, Emmanuel Ikechukwu Okolie, Innocent Onyesom. Hardy-Weinberg Equilibrium Study of Some Morphogenetic Traits in a Nigerian Population. Int J Anat Res 2024;12(1):8840-8848. DOI: 10.16965/ijar.2023.259