Type of Article:  Original Research

Volume 9; Issue 3.1 (July 2021)

Page No.: 8045-8053

DOI: https://dx.doi.org/10.16965/ijar.2021.143

The Effect of Age, Sex and Sport Practice on the Measurements of the Frontal Lobe of the Brain

Rasha M. Elshinety *1, Ahmed Abdelkader Guneid 1, Shimaa Mohammed Ashour Elkhwaga 2, Gaber Rashad Sediek Khalil 3, Ahmed Adel ElBeheiry 4, Elsayed Aly Mohamed Metwally 1.

*1 Faculty of Medicine, Anatomy Department, Alexandria University, Egypt.

2 Faculty of Physical Education for Girls, Department Of Health Sciences Alexandria University, Egypt.

3 Faculty of Faculty of Physical Education for Boys, Department Football Training, Alexandria University, Egypt.

4 Faculty of Medicine, Radiology Department, Alexandria University, Egypt.  

Corresponding Author: Dr. Rasha M. Elshinety, Faculty of Medicine, Anatomy Department, Alexandria University, Egypt. E-Mail: rashaelshinety@yahoo.com


Background: The frontal lobes make up two-thirds of the human brain, and their functions have long remained unclear. 
Aim of the work: measuring cortical thickness and volume in various parts of the frontal lobe in athletic football players and non-athletes, as well as age-related changes in both sexes, using high-resolution MRI.   
Subjects and methods: A 40 volunteers were divided into two groups: non-football players (20 each, 10 males and 10 females) and 60 non-athletes of various ages (10-20, 20-30, and 30-40) (10 participants from each gender for each group).
Results:  The height, weight and BMI are increased in sport male and female groups, The medial orbitofrontal, the pars orbitalis, the superior frontal  and  the frontal pole in the right frontal lobe in females in the sport group, the pars orbicularis and pars triangularis in the left frontal lobe is increased  significantly in the sport group, The medial orbitofrontal and pars triangularis are increased significantly in the left frontal lobe in the male group aged 10-20 years, The caudal middle frontal, the medial orbitofrontal, the paracentral, the  pars triangularis, the pars orbicularis and superior frontal gyrus are increased significantly in the female aged 10-20 years in the right frontal lobe  while the lateral orbitofrontal and the frontal pole increased significantly in the female aged 20-30 years and medial orbitofrontal and paracentral  in female aged 10-20 years in the left frontal lobe.
Conclusion: age, gender and physical exercise can affect different parameters of the frontal lobe of the brain.
Key words: volumetric, frontal lobe, exercise, High-resolution MRI.


[1]. Chayer C, Freedman M. Frontal lobe functions. Current Neurology and Neuroscience Reports. 2001;1(6):547-52.
[2]. Berchicci M, Lucci G, Di Russo F. Benefits of physical exercise on the aging brain: the role of the prefrontal cortex. J Gerontol A Biol Sci Med Sci. 2013;68(11):1337-41.
[3]. Zeestraten EA, Gudbrandsen MC, Daly E, de Schotten MT, Catani M, Dell’Acqua F, et al. Sex differences in frontal lobe connectivity in adults with autism spectrum conditions. Transl Psychiatry. 2017;7(4):e1090-e.
[4]. Asllani I, Slattery P, Fafard A, Pavol M, Lazar RM, Marshall RS. Measurement of cortical thickness asymmetry in carotid occlusive disease. Neuroimage Clin. 2016;12:640-4.
[5]. Butterfield DA, Reed T, Newman SF, Sultana R. Roles of amyloid β-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer’s disease and mild cognitive impairment. Free Radical Biology and Medicine. 2007;43(5):658-77.
[6]. Birnbaum R, Weinberger DR. Genetic insights into the neurodevelopmental origins of schizophrenia. Nature Reviews Neuroscience. 2017;18(12):727-40.
[7]. Chen AC, Etkin A. Hippocampal Network Connectivity and Activation Differentiates Post-Traumatic Stress Disorder From Generalized Anxiety Disorder. Neuropsychopharmacology. 2013;38(10):1889-98.
[8]. Sundman MH, Hall EE, Chen N-K. Examining the relationship between head trauma and neurodegenerative disease: A review of epidemiology, pathology and neuroimaging techniques. J Alzheimers Dis Parkinsonism. 2014;4:137.
[9]. Donna KB, Tanya K, Jason RF, David E, Frank W, Jeffrey TB. Sex differences in outcome following sports-related concussion. Journal of Neurosurgery. 2005;102(5):856-63.
[10]. Ryan JP, Atkinson TM, Dunham KT. Sports-Related and Gender Differences on Neuropsychological Measures of Frontal Lobe Functioning. Clinical Journal of Sport Medicine. 2004;14(1).
[11]. Guenette JP, Stern RA, Tripodis Y, Chua AS, Schultz V, Sydnor VJ, et al. Automated versus manual segmentation of brain region volumes in former football players. NeuroImage: Clinical. 2018;18:888-96.
[12]. Schoemaker D, Buss C, Head K, Sandman CA, Davis EP, Chakravarty MM, et al. Hippocampus and amygdala volumes from magnetic resonance images in children: Assessing accuracy of FreeSurfer and FSL against manual segmentation. NeuroImage. 2016;129:1-14.
[13]. FreeSurfer. FreeSurfer Software Suite. FreeSurfer 2013. Available from: (http://surfer.nmr.mgh.harvard.edu/
[14]. [Analytics IBM. IBM SPSS Software. Retrieved May. 2018;5:2018.
[15]. Taki Y, Kinomura S, Sato K, Inoue K, Goto R, Okada K, et al. Relationship between body mass index and gray matter volume in 1,428 healthy individuals. Obesity (Silver Spring, Md). 2008;16(1):119-24.
[16]. Iwashiro N, Suga M, Takano Y, Inoue H, Natsubori T, Satomura Y, et al. Localized gray matter volume reductions in the pars triangularis of the inferior frontal gyrus in individuals at clinical high-risk for psychosis and first episode for schizophrenia. Schizophrenia research. 2012;137(1-3):124-31.
[17]. Best JR, Chiu BK, Hall PA, Liu-Ambrose T. Larger Lateral Prefrontal Cortex Volume Predicts Better Exercise Adherence Among Older Women: Evidence From Two Exercise Training Studies. The Journals of Gerontology: Series A. 2017;72(6):804-10.
[18]. Nissim NR, O’Shea AM, Bryant V, Porges EC, Cohen R, Woods AJ. Frontal Structural Neural Correlates of Working Memory Performance in Older Adults. Front Aging Neurosci. 2017;8:328.
[19]. Koelkebeck K, Miyata J, Kubota M, Kohl W, Son S, Fukuyama H, et al. The contribution of cortical thickness and surface area to gray matter asymmetries in the healthy human brain. Hum Brain Mapp. 2014;35(12):6011-22.

Cite this article: Rasha M. Elshinety, Ahmed Abdelkader Guneid, Shimaa Mohammed Ashour Elkhwaga, Gaber Rashad Sediek Khalil, Ahmed Adel ElBeheiry, Elsayed Aly Mohamed Metwally. The Effect of Age, Sex and Sport Practice on the Measurements of the Frontal Lobe of the Brain. Int J Anat Res 2021;9(3.1):8045-8053. DOI: 10.16965/ijar.2021.143