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IJAR.2019.303

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Type of Article:  Original Research

Volume 8; Issue 1.2 (February 2020)

Page No.: 7277-7282

DOI: https://dx.doi.org/10.16965/ijar.2019.303

A STUDY OF INCIDENCE OF NEURAL TUBE DEFECTS AND THEIR PATTERN IN A TERTIARY CARE HOSPITAL OF GURUGRAM

Garg. S *1, Saxena. A. K 2, Aneja.P 3, Saha.S 4.

*1 Assistant Professor, Dept. of Anatomy, SGT Medical College Hospital & Research Institute, Gurugram, India.

2 Professor& HOD, Dept. of Anatomy, SGT Medical College Hospital & Research Institute, Gurugram, India.

3 Professor, Dept. of Anatomy, SGT Medical College Hospital & Research Institute, Gurugram, India.

4 Associate Professor, Dept. of Anatomy, SGT Medical College Hospital & Research Institute, Gurugram, India.

Corresponding Author: Dr. Shilpi Garg, Assistant Professor, Dept. of Anatomy, SGT Medical College Hospital & Research Institute, Gurugram, India. E-Mail: mdshilpi@gmail.com

ABSTRACT

Objective:  The study was undertaken to determine the proportion and pattern of Neural Tube Defects (NTD) reported at tertiary care teaching hospital in Gurugram. The incidence of NTDs were determined and compared with other studies done in India and other countries.

Material and methods: The study was carried out in SGT Medical College Hospital and Research Institute, Gurugram. The total number of deliveries was recorded from  2017-  2019.The aborted fetuses with NTDs were observed in detail externally for the sex, type of NTD and other associated anomalies after obtaining ethical clearance and written informed consent of the parents.

Results: The number of deliveries conducted between 2017-2019 at SGT Medical College Hospital and Research Institute, Gurugram was 2500. There were 8 babies born with NTDs (5 female and 4 male). Overall incidence of NTDs in the present study was 3.2/1000 births with female preponderance. The incidence of fetuses with anencephaly, myelocele, meningomyelocele, craniorachischisis and encephalocele were 0.8, 1.2, 0.4, 0.4, and 0.4 per 1000 births respectively.

Conclusion: Birth defects like Neural Tube Defects are easily detected by routine screening tests like USG in first and second trimester of pregnancy. Public health measures like preconception folic acid supplements and increasing awareness about maternal care during pregnancy needs to be highlighted to decrease the incidence of congenital anomalies and their comorbidities.

Key words: Neural tube defects (NTDs), Incidence, Anencephaly, Meningomyelocele, Myelocele, Craniorachischisis.

REFERENCES

  1. Kibar Z, Capra V, Gros P: Toward understanding the genetic basis of neural tube defects. Clin Genet.2007; 71:295-.310.
  2. Botto LD, Moore CA, Khoury MJ, et al. Neural-tube defects. N Engl J Med.1999; 341:1509-19.
  3. Rossi A, Biancheri R, Cama A, et al: Imaging in spine and spinal cord malformations. Eur J Radiol.2004; 50:177-200.
  4. Frey L, Hauser WA: Epidemiology of neural tube defects. Epilepsia.2003; 44:4-13.
  5. Mitchell LE: Epidemiology of neural tube defects. Am J Med Genet C Semin Med Genet135C.2005; 88-94.
  6. Lynch SA: Non-multifactorial neural tube defects. Am J Med Genet C Semin Med Genet 135C.2005; 69-76.
  7. Byrne J, Carolan S: Adverse reproductive outcomes among pregnancies of aunts and (spouses of) uncles in Irish families with neural tube defects. Am J Med Genet A.2006; 140:52-61.
  8. Deak KL, Siegel DG, George TM, et al: Further evidence for a maternal genetic effect and a sex-influenced effect contributing to risk for human neural tube defects. Birth Defects Res A Clin Mol Teratol .2008; 82:662-69.
  9. MRC, Vitamin Study Research Group: Prevention of neural tube defects: Results of the Medical Research Council Vitamin study. Lancet 338.1991; 131-37.
  10. Moore KL, Persaud TVN. Torchia MG. The Developing Human. Elseviers. 2013; (9) p57.
  11. Cragan JD, Roberts HE, Edmonds LD. Surveillance for anencephaly and spina bifida and impact of prenatal diagnosis in United States. 1985-1994. Mortal Morb Wkly Rep. 1995;44:113.
  12. Koumudi G, Urmila D, Chittaranjan Y. Nutri-genetic Determinants of Neural Tube Defects in India. Indian Pediatrics. 2009; 46:467-75.
  13. Verma IC. Burden of genetic disorders in India. Indian J Pediatr. 2000;67:893-98.
  14. Kulkarni ML, Mathew MA, Reddy V. The range of neural tube defects in southern India. Archives of Diseases in Childhood. 1989; 64:201-04.
  15. Mini S, Neera A, Shashi V, Bhargava SK. Neural tube defects in an East Delhi Hospital. Indian Journal of Pediatrics. 1991; 58:363-65.
  16. Sharada BM. A study of neural tube defects. J Anat Soc India. 2010; 59(2):162-67.
  17. Suresh NM, Dhananjay. Neural Tube Defects. Anatomica Karnataka. 2011; 5(1):61-64.
  18. Creasy MR, Alberman ED. Congenital malformation of the central nervous system in spontaneous abortion. J Med Genet.1976; 13:9-16.
  19. Greene ND, Copp AJ: Development of the vertebrate central nervous system: Formation of the neural tube. Prenat Diagn.2009; 29:303-11.
  20. Van AMI, Kalousek DK, Chernoff GF, et al: Evidence for multi-site closure of the neural tube in humans. Am J Med Genet.1993; 47:723-43.
  21. Catala M: Genetic control of caudal development. Clin Genet.2002; 61:89-96.
  22. Bassuk AG, Craig D, Jalali A et al: The genetics of tethered cord syndrome. Am J Med Genet A 132.2005; 450-53.
  23. Bainter JJ, BoosA, Kroll KL et al. Neural induction takes a transcriptional twist. Dev Dyn. 2001; 315-27.
  24. De Robertis EM, Kuroda H: Dorsal-ventral patterning and neural induction in Xenopus embryos. Annu Rev Cell Dev Biol.2004; 20:285-308.
  25. Stern CD: Neural induction: 10 Years on since the “default model”. Curr Opin Cell Biol. 2006; 18:692-97.
  26. Van der Linden IJ, Afman LA, Heil SG, et al. Genetic variation in genes of folate metabolism and neural-tube defect risk. Proc Nutr Soc.2006; 65:204-15.
  27. Rothenberg SP, da Costa MP, Sequeira JM, et al: Autoantibodies against folate receptors in women with a pregnancy complicated by a neural tube defect. N Eng J Med.2004; 350:134-42.
  28. Piedrahita JA, Oetama B, Bennett GD, et al: Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development. Nat Genet.1999; 23:228-32.
  29. Wallingford JB, Fraser SE, and Harland RM: Convergent extension: The molecular control of polarized cell movement during embryonic development. Dev Cell.2002; 2:695-706.
  30. Baker PN. Prenatal Diagnosis. In: Obstetrics by 10 teachers. Book Power publishers. Hodder Arnold. London. 2006; (18): 107-08.                                           

Cite this article: Garg. S, Saxena. A. K, Aneja. P, Saha. S. A STUDY OF INCIDENCE OF NEURAL TUBE DEFECTS AND THEIR PATTERN IN A TERTIARY CARE HOSPITAL OF GURUGRAM. Int J Anat Res 2020;8(1.2):7277-7282. DOI: 10.16965/ijar.2019.303