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IJAR.2019.227

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Type of Article:  Original Research

Volume 7; Issue 3.2 (August 2019)

Page No.: 6793-6799

DOI: https://dx.doi.org/10.16965/ijar.2019.227

SALIVARY ANTIOXIDANT STATUS FOLLOWING RADIOTHERAPY IN PATIENTS WITH HEAD AND NECK CANCER

Vinay Kumar .V.

Professor, Department of Anatomy, K.S. Hegde Medical Academy, Nitte (Deemed to be University), Deralakatte, Mangaluru, Karnataka, India.

Address for Correspondence:  Dr. Vinay Kumar .V, Professor, Department of Anatomy, K.S. Hegde Medical Academy, Nitte (Deemed to be University), Deralakatte, Mangaluru, Karnataka, India.  Ph: +917795767676. E-Mail: dr7795767676@gmail.com

ABSTRACT:

Background: Head and neck cancer (HNC) represents 3% of all the malignant tumours. It is the sixth most common human malignancy. Patients with head and neck cancer receiving radiotherapy are exposed to ionizing radiation which may damage normal tissue located in the field of radiation. The present study aims to determine the changes in antioxidants status of pre and post RT saliva samples of HNC patients

Materials and Methods: The pre and post radiotherapy saliva samples were collected from every patient with head and neck cancer. The changes in the antioxidant levels of saliva in pre and post radiotherapy saliva samples of head and neck cancer patients was determined.

Observation: The three biochemical parameters levels Malondealdehyde, Glutathione peroxidase, Myeloperoxidase decreased following radiotherapy. But the decrease was not statistically significant for Glutathione peroxidase and Myeloperoxidase and highly significant for Malondealdehyde.

Conclusion: The Total Antioxidant Capacity increased following radiotherapy and it was observed that after radiotherapy their increased levels were statistically not significant.

Key words: Saliva, Antioxidants, Radiotherapy, Head and neck cancer.

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Cite this article: Vinay Kumar. V. SALIVARY ANTIOXIDANT STATUS FOLLOWING RADIOTHERAPY IN PATIENTS WITH HEAD AND NECK CANCER. Int J Anat Res 2019;7(3.2):6793-6799. DOI: 10.16965/ijar.2019.227