IJAR.2018.444

Type of Article:  Original

Volume 7; Issue 1.2 (February 2019)

Page No.: 6211-6219

DOI: https://dx.doi.org/10.16965/ijar.2018.444

HISTOGENESIS OF HUMAN LUNG – RETROSPECTIVE FETAL AUTOPSY STUDY

Jessy J P *, Kanchan Kapoor #, Mahesh K Sharma #

* All India Institute Of Medical Sciences, New Delhi, India.

# Government Medical College & Hospital, Chandigarh, India.

Address for correspondence: Dr. Jessy J P, All India Institute Of Medical Sciences, New Delhi, India. E-Mail:  jesjp07@gmail.com

ABSTRACT:

Histogenesis of human fetal lung was studied in 40 human fetuses under light microscope after sectioning and staining with hematoxylin & eosin stain, in fetuses with gestational age ranging from 10 weeks to fetuses above 30 weeks. Appearance of various levels of bronchi were identified with the changes in the epithelium at different levels of bronchi. The appearance of alveolar ducts and few alveoli were recognized after 25 weeks of gestation. Vascularisation of the fetal lung was observed as early as 10 weeks of gestation. Appearance of various levels of bronchi were identified with the changes in the epithelium at different ages of gestation.

Key words: Fetal Lung, Bronchi, Respiratory Distress, Alveolar Ducts, Alveoli.

REFERENCES

  1. Naik SK, Madhavi K, Gurushanthaiah M, Mahesh GM. Development and histogenesis of human foetal lung in relation with gestational age. Int J Res Med Sci 2014; 2(3):1117-20.
  2. Moore KL, Persaud TVN, Torchia MG. Respiratory system. In: The developing human. 9th India: Elesvier; 2013  p 204-211.
  3. Hislop AA. Airway and blood vessel interaction during lung development. J Anat 2002; 201(4):325-34.
  4. Bucher U and Reid L. Development of the intrasegmental bronchial tree: the pattern of branching and development of cartilage at various stages of intrauterine life. Thorax 1961; 16:207-18
  5. Palmer DM. Early developmental stages of the human lung. Ohio J Sci 1936a; 36:69-79.
  6. Palmer DM. The lung of a human foetus of 170 mm. C. R. length. AmJ Anat1936b; 58(1):59-72.
  7. Brenek IZ. Mikr-anat. Forsch 1941; 49:525.
  8. Policard A and Galy P. Les Bronches. Masson. 1945. Paris
  9. Campiche MA, Gautier A, Hernandez EI, Reymond A. An electron microscope study of the fetal development of human lung. Pediatrics 1963;976-94.
  10. Jeffery PK, Gaillard D, Moret S. Human airway secretory cells during development and in mature airway epithelium. Eur Respir J 1992; 5:93-104.
  11. Tos M. Development of the mucous glands in the human main bronchus. Anatomischer Anzeiger 1968; 123:376-89.
  12. Bucher U and Reid L. Development of mucus secreting elements of the lung. Thorax 1961; 16:219-25.
  13. Tanaka O, Oki M, Shimatsu A. Histogenetic study on fetal lungs. Shimane J. Med. Sci 1980; 4:81-90.
  14. Kate DR, Sant SM. Histogenesis of human foetal lung: A light microscopic study. IOSR-JDMS 2013; 9(2):01-08.
  15. Cooper ERA. A histological investigation of the development and structure of the human lung. Journal of pathology 105-14.
  16. Baskerville A. Histological and ultrastuctural observations on the development of the lung of the fetal pig. Acta anat 1976; 95:218-33.
  17. Hishop A, Reid L. Fetal and childhood development of intrapulmonary veins in man- branching pattern and structure. Thorax 1973.; 28:313-19.
  18. Pessaco TP. Considerations on the architectonics of alveolar blood vessels in the lung of the human newborn. Acta Anat 1972; 82:118-25.
  19. Takahashi M, Murata K, Mishina A, Mori M, Shimoyama K and Morita R. Side branches of pulmonary artery in the hilar region. Acta Anat 1994; 150:150-55.
  20. Hishop AA, and Haworth SG. Pulmonary vascular damage in the development of cor pulmonale following hyaline membrane disease. Paediat. Pulmon 1990; 9:152-61. 

Cite this article: Jessy J P, Kanchan Kapoor, Mahesh K Sharma. HISTOGENESIS OF HUMAN LUNG – RETROSPECTIVE FETAL AUTOPSY STUDY. Int J Anat Res 2019;7(1.2):6211-6219. DOI: 10.16965/ijar.2018.444