Type of Article:  Original

Volume 7; Issue 1.2 (February 2019)

Page No.: 6166-6170

DOI: https://dx.doi.org/10.16965/ijar.2018.428


Bhavin B. Kodiyatar 1, Brijesh M. Patel *2, Viren B. Kariya 3.

1 Assistant Professor, Anatomy Department, B.J. Medical College, Ahmedabad, Gujarat, India.

*2 Assistant Professor, Anatomy Department, B.J. Medical College, Ahmedabad, Gujarat, India.

3 Associate Professor, PDU Medical College, Rajkot, Gujarat, India.

Corresponding Author: Dr.Brijesh M. Patel,  01, Riddhi Siddhi tenamnets, Near Bhavana raw house society, Ranip, Ahmedabad, Gujarat-382480, India. Mobile: 07984682125 E-Mail: brijpatelbjmc@gmail.com


Introduction: Infertility is a major health problem in 10-15% Indian couples affecting their psychological and social wellbeing. There is increasing recognition to the contribution of genetic abnormalities to the causation of male infertility. Genetics play a important role in infertility by controlling the physiological processes including hormonal factors, spermatogenesis, and sperm quality. The aim of the study was to find out the Chromosomal abnormalities that play a major role in male infertility cases with non-obstructive azoospermia and oligospermia. The timely investigation to detect genetic abnormality gives better understanding about prognosis to the patients and helps in providing genetic counseling with early intervention, management and also understanding risks involved in transmission of abnormality to future generations.

Materials and methods: In present study total 30 male cases of primary infertility clinically diagnosed and conformed by semen analysis as unobstructed azoospermia and oligospermia were selected.  Their karyotypes were prepared and studied for chromosomal abnormalities

Result: The Numerical chromosomal abnormality was found in 2 (6.66%) cases of azoospermic group in the form of Klinefelter syndrome (47,XXY).  In cases of oligospermia 1 (3.34%) case had an abnormality in the form of Robertsonian translocation involving 14:15 chromosome. The total 3 cases (10%) were found to have gross chromosomal abnormality by conventional cytogenetic method.

Conclusion: In cases of Klinelfelter syndrome (47,XXY) due to altered karyotype or due to meiotic non-disjunction, the residual gametes may be extracted through Testicular / Epididymal Sperm Aspiration (TESA). It is necessary that the diagnosis be made as soon as possible, so as to guarantee the cryopreservation of the semen before complete infertility sets in.

Key words: Infertility, Karyotypes, Klinefelter syndrome, Azoospermia, Oligospermia.


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Cite this article: Bhavin B. Kodiyatar, Brijesh M. Patel, Viren B. Kariya. KARYOTYPE ANALYSIS IN CASES OF PRIMARY MALE INFERTILITY. Int J Anat Res 2019;7(1.2):6166-6170. DOI: 10.16965/ijar.2018.428