Type of Article:  Original Research

Volume 6; Issue 4.1 (October 2018)

Page No.: 5820-5829

DOI: https://dx.doi.org/10.16965/ijar.2018.350


Asmaa Mohammed Tolba *1, Samia Hussein 2.

*1 Anatomy and Embryology Department, Faculty of medicine, Zagazig University, Egypt .

2 Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Zagazig University, Egypt.

The corresponding authors’ address: Dr. Asmaa Mohammed Tolba, Anatomy and Embryology Department, Faculty of medicine, Zagazig University, 44519, Egypt. tel: 002 01142203098 E-Mail : amtolba@zu.edu.eg


Background: Potassium dichromate (K2Cr2O7) is a major environmental pollutant and is known for its wide toxic manifestations. The present study shows the protective role of selenium (Na2SeO3) against chromium induced hepatorenal toxicity.

Materials and Methods: Sixty  adult albino rats were divided into four groups of fifteen each. Group I is control group which received standard diet; group II received K2Cr2O7 (67mg/kg B.W) in drinking water; group III received selenium only (0.5 μg/kg B.W) and group IV received both K2Cr2O7 (67mg/kg B.W) and selenium (0.5 μg/kg B.W) for 6 weeks.

Results: Selenium supplementation to the group IV improved all the kidney and liver chemical function parameters. In addition, it down-regulates endoplasmic reticulum stress genes.

Conclusion: The biochemical results confirmed the improvement of histopathological findings. Therefore, our study revealed that selenium  was effective in preventing K2Cr2O7-induced hepatorenal toxicity.

Key words: Selenium, hepatorenal, Potassium dichromate, PCR, Rats.


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Cite this article: Asmaa Mohammed Tolba, Samia Hussein. SELENIUM MODULATES HEPATORENAL DAMAGE AND GENOTOXICITY INDUCED BY POTASSIUM DICHROMATE IN ADULT ALBINO RATS. Int J Anat Res 2018;6(4.1):5820-5829. DOI: 10.16965/ijar.2018.350