IJAR.2018.350
Type of Article: Original Research
Volume 6; Issue 4.1 (October 2018)
Page No.: 5820-5829
DOI: https://dx.doi.org/10.16965/ijar.2018.350
SELENIUM MODULATES HEPATORENAL DAMAGE AND GENOTOXICITY INDUCED BY POTASSIUM DICHROMATE IN ADULT ALBINO RATS
Asmaa Mohammed Tolba *1, Samia Hussein 2.
*1 Anatomy and Embryology Department, Faculty of medicine, Zagazig University, Egypt .
2 Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Zagazig University, Egypt.
The corresponding authors’ address: Dr. Asmaa Mohammed Tolba, Anatomy and Embryology Department, Faculty of medicine, Zagazig University, 44519, Egypt. tel: 002 01142203098 E-Mail : amtolba@zu.edu.eg
ABSTRACT:
Background: Potassium dichromate (K2Cr2O7) is a major environmental pollutant and is known for its wide toxic manifestations. The present study shows the protective role of selenium (Na2SeO3) against chromium induced hepatorenal toxicity.
Materials and Methods: Sixty adult albino rats were divided into four groups of fifteen each. Group I is control group which received standard diet; group II received K2Cr2O7 (67mg/kg B.W) in drinking water; group III received selenium only (0.5 μg/kg B.W) and group IV received both K2Cr2O7 (67mg/kg B.W) and selenium (0.5 μg/kg B.W) for 6 weeks.
Results: Selenium supplementation to the group IV improved all the kidney and liver chemical function parameters. In addition, it down-regulates endoplasmic reticulum stress genes.
Conclusion: The biochemical results confirmed the improvement of histopathological findings. Therefore, our study revealed that selenium was effective in preventing K2Cr2O7-induced hepatorenal toxicity.
Key words: Selenium, hepatorenal, Potassium dichromate, PCR, Rats.
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