Type of Article:  Original Research

Volume 6; Issue 4.1 (October 2018)

Page No.: 5754-5759

DOI: https://dx.doi.org/10.16965/ijar.2018.335


Vidya H.K 1, Krishnaveni Sharath *2, Asha K.R 3.

1 Assistant Professor, Department of Anatomy, Sridevi Medical college & Hospital, Tumkur, Karnataka, India.

*2 Assistant Professor, Department of Anatomy, SreeBalaji Medical College & Hospital, BIHER, Chrompet, Chennai, Tami Nadu, India.

3 Assistant Professor, Department of Anatomy, Sri Siddhartha Medical College &Hospital, Tumkur, Karnataka, India.

Corresponding author: Dr Krishnaveni Sharath, Assistant Professor, Department of Anatomy, Sree Balaji Medical College, BIHER,  Chrompet, Chennai, Tamil Nadu, India. E-Mail: doc_krisu@yahoo.co.in Phone: 9061745504


Background: Down syndrome being the most common chromosomal disorder is researched extensively. The only etiology that is well established is increased maternal age. In the developing countries, the incidence of Down syndrome is increasing in younger mother.

Method: 75 cases of Down syndrome children and age matched 75 children without known congenital abnormalities were taken for this study. The parental age was noted and statistical analysis was done to correlate the maternal age withy DS.

Result: Only 26.4% of DS children were born in mothers aged above 35. There was a decrease in number of children born in aged mothers of both group, but there was no much difference in the groups.

Conclusion: Maternal age is not only the risk factor for occurrence of DS. There is generally a tendency of early pregnancy in India, which leads to increase in number of DS children being born to mothers below 35.

Key words: Down syndrome, Maternal age.


  1. Kumar P, Gupta A, Fotra R, Upma, Raina S, Sethi S, et al. Chromosomal anomalies in referred cases with suspected genetic disorders: First report from Jammu and Kashmir. Int J Hum Genet. 2010;
  2. Regina Mary1, K.M.Gothandam2* TLM. Increased frequency of down syndrome in young mothers of rural population. J Ecobiotechnology [Internet]. 2010 Aug 23 [cited 2017 Dec 24];2(3). Available from: http://scienceflora.org/journals/index.php/jebt/article/view/38
  3. Welcome to Down Syndrome Federation of India – Official Website [Internet]. [cited 2018 Mar 11]. Available from: http://www.downsyndrome.in/faq.php
  4. Priya Ranganathan, Ann Agnes mathew SR. Cardinal Features:Down syndrome. South Asian Anthropol. 2005;5(1):97–101.
  5. Dzurova D, Pikhart H. Down syndrome, paternal age and education: Comparison of California and the Czech Republic. BMC Public Health [Internet]. 2005 Dec 17 [cited 2017 Dec 24];5(1):69. Available from: http://bmcpublichealth.biomedcentral.com/articles/10.1186/1471-2458-5-69
  6. Margaret M, Amudha S, Tilak P, Devi R, Rajangam S. Cytogenetic Analysis in Down Syndrome. Int J Hum Genet. 2010;10(3):95–9.
  7. Moses V, Dalal N. Pregnancy outcome in elderly primi gravidas. Int J Reprod Contraception, Obstet Gynecol. 2016;5(11):3731–5.
  8. Kazaura MR, Lie RT, Skjaerven RS. Grandparents’ age and the risk of Down’s syndrome in Norway. Acta Obstet Gynecol Scand [Internet]. 2006 [cited 2018 Mar 10];85(2):236–40. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16532921
  9. Census of India: Age Structure And Marital Status [Internet]. 2011 [cited 2018 Mar 10]. Available from: http://censusindia.gov.in/Census_And_You/age_structure_and_marital_status.aspx
  10. Kothare S, Shetty N, Dave U. Maternal Age and Chromosomal Profile in 160 Down Syndrome Cases – Experience of a Tertiary Genetic Centre from India. 2002;
  11. Azman B Z, Ankathil R, Siti Mariam I, Suhaida M A, Norhashimah M, Tarmizi A B, Nor Atifah M A, Kannan T P ZBA. Cytogenetic and clinical profile of Down syndrome in Northeast Malaysia. Singapore Med J. 2007;48(6):550–4.
  12. Pavarino Bertelli EC, Biselli JM, Bonfim D, Goloni-Bertollo EM. Clinical profile of children with Down syndrome treated in a genetics outpatient service in the southeast of Brazil. Rev Assoc Med Bras [Internet]. 2009 [cited 2017 Dec 24];55(5):547–52. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302009000500017&lng=en&nrm=iso&tlng=en
  13. Sheth F, Rao S, Desai M, Vin J, Sheth J. Cytogenetic analysis of Down syndrome in Gujarat. [Internet]. Vol. 44, Indian pediatrics. 2007 [cited 2017 Dec 24]. p. 774–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17998578
  14. Bernice H Cohen, Abraham M llilienfeld ATS. Some Epidemilogical Aspects of Mongolism: A Review. AJPH. 1963;53(2):223–36.
  15. KOCHUPILLAI N, VERMA IC, GREWAL MS, RAMALINGASWAMI V. Down’s syndrome and related abnormalities in an area of high background radiation in coastal Kerala. Nature [Internet]. 1976 Jul 1 [cited 2018 Mar 13];262(5563):60–1. Available from: http://www.nature.com/articles/262060a0
  16. James SJ, Pogribna M, Pogribny IP, Melnyk S, Hine RJ, Gibson JB, et al. Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome. Am J Clin Nutr [Internet]. 1999 Oct 1 [cited 2018 Mar 12];70(4):495–501. Available from: https://academic.oup.com/ajcn/article/70/4/495/4729077
  17. Vundinti BR, Ghosh K. Incidence of down syndrome: Hypotheses and reality. Indian J Hum Genet [Internet]. 2011 Sep [cited 2018 Mar 10];17(3):117–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22345980
  18. COPPEN A, COWIE V. Maternal health and mongolism. Br Med J [Internet]. 1960 Jun 18 [cited 2018 Mar 13];1(5189):1843–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/13811863
  19. Bernice H Cohen, Abraham M llilienfeld ATS. Some epidemiological aspects of mongolism: A review. AJPH. 1963;53(223–236).
  20. Crane E, Morris J. Changes in maternal age in England and Wales – implications for Down syndrome. Down Syndr Res Pract [Internet]. 2006 [cited 2017 Dec 25];10(1):41–3. Available from: http://www.down-syndrome.info/library/periodicals/dsrp/10/01/
  21. Malini SS, Ramachandra NB. Influence of advanced age of maternal grandmothers on Down syndrome. BMC Med Genet [Internet]. 2006 Dec 14 [cited 2018 Mar 12];7(1):4. Available from: http://bmcmedgenet.biomedcentral.com/articles/10.1186/1471-2350-7-4
  22. Chandra N, Cyril C, Lakshminarayana P, Nallasivam P, Ramesh A, Gopinath PM, et al. Cytogenetic evaluation of Down syndrome: A Review of 1020 Referral cases. Int J Hum Genet 10(1-3) 1-14. 2010;10(1–3):87–93.

Cite this article: Vidya H.K, Krishnaveni Sharath, Asha K.R. RISK OF DOWN SYNDROME IN ELDERLY MOTHERS: A RETROSPECTIVE STUDY IN TUMKUR. Int J Anat Res 2018;6(4.1):5754-5759. DOI: 10.16965/ijar.2018.335