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IJAR.2018.229

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Type of Article:  Original Research

Volume 6; Issue 3.1 (July 2018)

Page No.: 5445-5448

DOI: https://dx.doi.org/10.16965/ijar.2018.229

CORPORA AMYLAECIA DEPOSITION IN THE OLFACTORY BULB AND TRACT IN AGEING AND ALZHEIMER’S DISEASE

Monali  Sonawane 1, Aruna Mukherjee 2, Pravin  Rathod *3.

1 PhD Scholar/Associate Professor, Department of Anatomy, M.G.M Institute of Health Sciences, Navi Mumbai, Maharashtra, India.

2 Professor, Department of Anatomy, M.G.M Medical College, Navi Mumbai, Maharashtra, India.

*3 PhD Scholar/Lecturer, Department of Anatomy, M.G.M Institute of Health Sciences, Navi Mumbai, Maharashtra, India.

Corresponding Author: Pravin Raghunath Rathod, PhD Scholar/Lecturer, Department of Anatomy, M.G.M Institute of Health Sciences, Navi Mumbai, Maharashtra, India-410209. Tel -002227433404 E-Mail: drpravinrathod123@gmail.com

ABSTRACT

Background:  The olfactory system has several interesting anatomical and physiological features although olfaction has remained a ‘neglected sense’. Olfactory functioning is a valid indicator of the ageing brain so present study was designed to investigate the age of appearance of corpora amylaecia in the olfactory bulb and tract and compare with well known cases of Alzheimer’s disease.

Aims of the study: To detect deposition of corpora amylaecia in the human olfactory bulb and tract in different age groups and Alzheimer’s disease.

Materials and Methods:  22 brain specimens were collected from cadavers from Anatomy department of MGM Medical College, Navi Mumbai and from National Institute of Mental Health and Sciences (NIMHANS), Bangalore. The study was carried out in 20 undemented specimen, divided into four groups (5 samples in each) according to age: group I (20-39yrs), group II(40-59yrs),group III (60-79yrs),group IV(80 yrs and above) and 2 specimen of Alzheimer’s disease as a control group. Histological evaluation was done with Haematoxylin and Eosin stain, Luxol fast blue stain and Immunohistological stain, Glial fibrillary acidic protein (GFAP) antibody to study corpora amylaecia. Statistical analysis was carried out using Chi Square test.

Results: In group II, 20%, in Group III and Group IV 80% samples have showed presence of corpora amylaecia. In controls 100% samples had corpora amylaecia. This difference between five groups was statistically significant. In group II, corpora amylaecia was small in size, circular, deeply basophilic and scattered. In group III, IV and V, corpora amylaecia was large in size, more in number and condensed.

Conclusion: The present study concluded that corpora amylaecia appear as early as fifth decade of life. Corpora amylaecia are age and neurodegeneration related phenomena and their number and size increase with age. Deposition of the corpora amylaecia in the olfactory bulb and tract may be responsible for olfactory dysfunction in advanced age and neurodegenerative disorders

Key words: Corpora Amylaecia, Olfactory Bulb, Olfactory Tract.

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Cite this article: Monali Sonawane, Aruna Mukherjee, Pravin Rathod. CORPORA AMYLAECIA DEPOSITION IN THE OLFACTORY BULB AND TRACT IN AGEING AND ALZHEIMER’S DISEASE. Int J Anat Res 2018;6(3.1):5445-5448. DOI: 10.16965/ijar.2018.229