IJAR.2018.220

Type of Article:  Original Research

Volume 6; Issue 3.3 (Septmber 2018)

Page No.: 5593-5596

DOI: https://dx.doi.org/10.16965/ijar.2018.220

BUCCAL MUCOSAL DNA DAMAGE FOLLOWING RADIOTHERAPY IN PATIENTS WITH HEAD AND NECK CANCER

Vinay Kumar V 1, Sachin KS *2, Vishak R 3.

*1 Professor, Department of Anatomy, K S Hegde Medical Academy, Deralakatte, Mangaluru, Karnataka, India.
2 Assistant Professor, Department of Anatomy, K S Hegde Medical Academy, Deralakatte, Mangaluru, Karnataka, India.

3 Department of Anatomy, K S Hegde Medical Academy, Deralakatte, Mangaluru, Karnataka, India.

Address for Correspondence: Dr. Sachin KS, Assistant Professor, Department of Anatomy, K S Hegde Medical Academy, Deralakatte, Mangaluru- 575018. Karnataka, India. PH 7795767676. E-Mail:   dr7795767676@gmail.com

ABSTRACT:

Patients with head and neck cancer receiving radiotherapy in addition to antitumour effects also are exposed to ionizing radiation which may also damage normal tissue located in the field of radiation. The study was done on buccal scrapings in patients with head and neck cancer patients receiving radiotherapy at the hospital.  The present study aims at determining the changes in MN in the buccal smears in pre and post RT in patients with head and neck cancer patients. The mean number of MN was significantly high in buccal scrapings of patients post RT suggesting DNA damage following exposure to radiations during RT.

Key Words: Head and neck cancer, Radiotherapy, Micronucleus assay, Buccal mucosa.

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Cite this article: Vinay Kumar V, Sachin KS, Vishak R. BUCCAL MUCOSAL DNA DAMAGE FOLLOWING RADIOTHERAPY IN PATIENTS WITH HEAD AND NECK CANCER. Int J Anat Res 2018;6(3.3):5593-5596. DOI: 10.16965/ijar.2018.220