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IJAR.2017.424

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Type of Article:  Original Research

Volume 6; Issue 1.1 (January 2018)

Page No.: 4788-4793

DOI: https://dx.doi.org/10.16965/ijar.2017.424

ROLE OF WITHANIA SOMNIFERA AND IT’S ACTIVE PRINCIPLE WITHANOLIDE-A IN BALANCE AND MOTOR CO-ORDINATION BY FOOT PRINT TEST

A. Mary Antony Praba *1, C.Venkataramaniah 2, Kavitha Ganesh 3, Krishna Eswari 4.

*1 Associate Professor, Department of Anatomy, Tagore Medical College, Chennai, Tamilnadu, India.

2 Professor, Department of Anatomy, Tagore Dental College, Chennai, Tamilnadu, India.

3 Reader, Department of Anatomy, Tagore Dental College, Chennai, Tamilnadu, India.

4 Reader, Department of Anatomy, Tagore Dental College, Chennai, Tamilnadu, India.

Address for the Correspondence: Dr. A. Mary Antony Praba. Associate Professor, Department of Anatomy, Tagore Medical College, Chennai, Tamilnadu, India. E-Mail: fio7rio@yahoo.co.in

ABSTRACT:

Background: The basal ganglia historically been considered as a part of the motor system because of the variety of motor deficits that occur when they are damaged. But now it is considered as “extrapyramidal” motor system, and the disorders of basal ganglia are called extrapyramidal disorders. One type of symptoms that result from basal ganglia disorders is called as Huntington’s Chorea. As this disorder involves with symptoms like dyskinesias – abnormal involuntary movements, we felt it is necessary to protect our nervous system from such a disorder if possible in a painless regular fashion by a herb.

Materials and Methods: We used adult male Sprague Dawly rats for this study. Animals were divided into 5 groups and were given either Withania somnifera extract or the active component Withanolide A in different concentrations 10 days prior to lesion surgery and continued 5 days post surgery. The neuroprotective role of the drug employed was analyzed on the 5th day post lesion by using foot print test in a run way.

Result:  The gait and balance of the animals were taken as a measure to analyze the protective nature of the striatum and so the activity of the drug employed here. The gait and balance of the LC animals were poor stating the unprotective nature of striatum. But the balance and gait of both drug group animals were comparatively better than the LC animals. That clearly stated the neuroprotective capacity of both the drugs used for this study.

Conclusion: Based on the observations and results we came to a conclusion that both the ethanolic extract and the active component withanolide A have the capacity in protecting the striatum and so can be used as a food supplement on a daily basis to protect our striatum. If needed further research can be conducted to analyze deep into the therapeutic effects of these herbal drugs.

Key words: Basal ganglia, Extrapyramidal, Huntington’s Chorea, Dyskinesias, Withania somnifera, Withanolide A, Gait, Striatum.

REFERENCES

  1. Obeso JA, Rodríguez-Oroz MC, Benitez-Temino B et al. Functional organization of the basal ganglia: therapeutic implications for Parkinson’s disease. Mov Disord. 2008;23(3):48-59.
  2. Stocco, Andrea, Lebiere et al. “Conditional Routing of Information to the Cortex: A Model of the Basal Ganglia’s Role in Cognitive Coordination”. Psychological Review. 2010:117(2): 541–74.
  3. Rosenblatt A, Leroi I. Neuropsychiatry of Huntington’s disease and other basal ganglia disorders. Psychosomatics. 2000:41(1):24-30.
  4. Helms A. Shulman L. Chorea, Athetosis, and Ballismus. Demos Medical Publishing. Bookshelf ID: NBK7479.
  5. Pollard J. A Caregiver’s Handbook for Advanced-StageHuntington Disease. Huntington Society of Canada. 2000.
  6. Jawaid T, Shukla D, Verma J. Anti-inflammatory activity of the plants used in traditional medicines. Int J of Bio Research. 2011;2(4):252‐263.
  7. Elayaraja A, Vijayalakshmi M, Devalarao G. In vitro free radical scavenging activity of various root and rhizome extracts of acorus calamus International journal of pharma and bio sciences. 2010:1(4):301.
  8. Mohan, Royce. Withanolide compounds as inhibitors of fibrosis and identification of molecular targets for anti-fibrotic drug development. http://www.freepatentsonline.com/y2008/0032958.html
  9. Carter RJ, Lione LA, Humby T et al. Characterization of Progressive Motor Deficits in Mice Transgenic for the Human Huntington’s Disease Mutation. The Journal of Neuroscience.1999:19(8):3248–3257.
  10. Venkatramaniah C, Praba AMA, Girija S. A model of temporal lobe epilepsy induced by kainic acid and the behavioral study of the animals treated with Acorus calamus and β-asarone. Journal of Pharmaceutical Sciences and Biomedical Sciences (JPBMS). 2012; 23(27):1-4.
  11. Longo BM, Mello LE. Supragranular mossy fiber sprouting is not necessary for spontaneous seizures in the intrahippocampal kainate model of epilepsy in the rat. Epilepsy Res. 1998;32(1-2):172-82.
  12. McGinty JF, Henriksen SJ, Goldstein A, et al. Dynorphin is contained within hippocampal mossy fibers: Immunochemical alterations after kainic acid Administration and colchicines induced Proc. Natl acad. Sci. Usa. 1983;80:589-593.
  13. Vandeputte C, Taymans JM, Casteels C et al. Automated quantitative gait analysis in animal models of movement disorders. BMC Neuroscience. 2010:11:92.

Cite this article: A. Mary Antony Praba, C.Venkataramaniah, Kavitha Ganesh, Krishna Eswari. ROLE OF WITHANIA SOMNIFERA AND IT’S ACTIVE PRINCIPLE WITHANOLIDE-A IN BALANCE AND MOTOR CO-ORDINATION BY FOOT PRINT TEST. Int J Anat Res 2018;6(1.1):4788-4793. DOI: 10.16965/ijar.2017.424