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IJAR.2017.252

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Type of Article:  Original Research

Volume 5; Issue 3.1 (July 2017)

Page No.: 4067-4072

DOI: https://dx.doi.org/10.16965/ijar.2017.252

PROTECTIVE ROLE OF ACORUS CALAMUS AND BETA ASARONE IN EXPLORATION AND ANXIETY LEVELS ON EXPERIMENTAL EPILEPTIC RAT MODEL

C.Venkatramaniah 1, A. Mary Antony Praba *2, Kavitha Ganesh 3.

1 Professor, Department of Anatomy, Tagore Dental College, Chennai, Tamilnadu, India.

*2 Associate Professor, Department of Anatomy, Tagore Medical College, Chennai, Tamilnadu, India.

3 Professor, Department of Anatomy, Princess Noura Bint Abdulrahman University, Riyadh, Saudi Arabia.

Address for Correspondence: Dr. A. Mary Antony Praba. Associate Professor, Department of Anatomy, Tagore Medical College,  Chennai, Tamilnadu, India. E-Mail: fio7rio@yahoo.co.in

ABSTRACT:

Background: The hippocampus is a major component of the brain. Damage to hippocampus results in profound difficulties in forming new memories and to some extend affects memories formed before the damage, anxiety and movement restriction. As our memory plays a major role on our daily activities and exploration plays a very big role in developing the society, we planned a  study to analyze the difficulties of hippocampal lesion and to find a way to prevent this situation by using some neuroprotective herbal drugs.

Materials and Methods: We used adult male Sprague Dawly rats for this study. Animals were divided into 8 groups and were given the drugs Acorus calamus extract or its active principle Beta Asarone in different concentration 10 days prior to lesion surgery and 10 post operative days intraperitoneally (IP) . The neuroprotective role of the drug employed was studied by analyzing the level of special exploration and anxiety of the animals.

Result: The LC group animals restricted their movements due to anxiety. They also had a very high latency period. But the drug treated animals were showing a good level of exploration by moving freely on the field also they scored less latency for their credit. Between the drug groups the Beta Asarone group brought into view an upper hand than Acorus calamus.

Conclusion: Based on the study it was concluded though both the drugs were smart enough to act and protect the nervous system, beta Asarone is more specific and the dosage BC20 was found more apt for the applied purpose.

KEY WORDS: Hippocampus, Memory, Hippocampal Lesion, Acorus Calamus, Beta Asarone.

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Cite this article: C.Venkatramaniah, A. Mary Antony Praba, Kavitha Ganesh. PROTECTIVE ROLE OF ACORUS CALAMUS AND BETA ASARONE IN EXPLORATION AND ANXIETY LEVELS ON EXPERIMENTAL EPILEPTIC RAT MODEL. Int J Anat Res 2017;5(3.1):4067-4072. DOI: 10.16965/ijar.2017.252