Type of Article:  Original Research

Volume 5; Issue 2.3 (June 2017)

Page No.: 3882-3890

DOI: https://dx.doi.org/10.16965/ijar.2017.179


Ajay Babu Kannabathula *1, Gunjan Rai 2   Himadri Sunam 1.

*1 Assistant Professor, Department of Anatomy, Gouri Devi Institute of Medical Sciences and Hospital, Durgapur, West Bengal, India.

2 Assistant Professor, Dept of Anatomy, Heritage Institute of Medical Sciences, Varanasi, U.P, India.

Address for Correspondence: Dr. Ajay Babu Kannabathula, Assistant Professor Gouri Devi Institute of Medical Sciences and Hospital, Durgapur, West Bengal, India. E-Mail: ajaykbabu57@gmail.com


Introduction: The Circle of Willis is a vascular network formed at the base of skull in the interpeduncular fossa. Its anterior part is formed by the anterior cerebral artery, from either side. Anterior communicating artery connects the right and left anterior cerebral arteries. Posteriorly, the basilar artery divides into right and left posterior cerebral arteries and each joins to ipsilateral internal carotid artery through a posterior communicating artery. Anterior communicating artery and posterior communicating arteries are important component of circle of Willis, acts as collateral channel to stabilize blood flow. In the present study, anatomical variations in the circle of Willis were noted.

Materials and Methods: 75 apparently normal formalin fixed brain specimens were collected from human cadavers. 55 Normal anatomical pattern and 20 variations of circle of Willis were studied. The Circles of Willis arteries were then coloured, photographed, numbered and the abnormalities, if any, were noted.

Result: Twenty variations were noted. The most common variation observed is in the anterior communicating artery followed by some other variations like the Posterior communicating arteries, Anterior Cerebral Artery and posterior cerebral artery was found in 20 specimens.

Conclusion: Knowledge on of variations in the formation of Circle of Willis, all surgical interventions should be preceded by angiography.  Awareness of these anatomical variations is important in the neurovascular procedures.

Key Words: Circle of Willis (CW), Variations of Circle of Willis, Hypoplastic and Aplastic Anterior Cerebral Arteries (ACA), Duplication of Anterior Communicating artery (ACoA) Fused ACoA, and triplication of Anterior Communicating Artery.


  1. Moorehead KT, Moore SM, Chase JG, David T, Fink J. 1D and 3D models of auto- regulated cerebrovascular flow. J Biomech Eng 2005; 127:440-9.
  2. William AN. Thomas Willis’ understanding of cerebrovascular disorders. J Stroke Cerebrovasc Dis 2003; 12:280-4.
  3. Ustun C. Dr. Thomas Willis’ famous eponym: the circle of Willis. Turk J Med Sci 2004; 34:271-4.
  4. Paul S, Mishra S. Variations of the anterior cerebral artery in human cadavers: a dissection study. J Anat Soc India 2004;53:15-6.
  5. Alpers BJ, Berry RG. Circle of Willis in cerebral vascular disorders. Arch Neurol 1963; 8:398-402.
  6. Riggs HE, Rupp C. Variations in form of circle of Willis. Arch Neurol 1963; 8:8-14.
  7. Fisher CM. The circle of Willis: anatomical variations. Vasc Dis 1965; 2:99-105.
  8. Puchades-Orts A, Nombela-Gomez M, Ortuno-Pacheco G. Variations in form of circle of Willis: some anatomical and embryological considerations. Anat Rec 1975; 185:119-23.
  9. Ashwini CS, Shubha R, Jayanthi KS. Comparative anatomy of the circle of Willis in man, cow, sheep, goat and pig.Neuroanatomy 2008; 7:54-65.
  10. Tanaka H, Fujita N, Enoki T, Matsumoto K, Watanabe Y, Nakamura H. Relationship between variations in the circle of Willis and flow rates in internal carotid and basilar arteries determined by means of magnetic resonance imaging with semi-automated lumen segmentation: reference data from 125 healthy volunteer. Am J Neuroradiol 2006;27:1770-5.
  11. Sforza DM, Putman CM, Cebral JR. Hemodynamics of cerebral aneurysms. Annu Rev Fluid Mech 2009;41:91-107.
  12. E. Orlandini, C. Ruggiero, S. Zecchi Orlandini, M.Gulisano. Blood vessel size of circulus arteriosus cerebri (Circle of Willis): a statistical research on 1000 human subjects. Acta Anatomica 1985;123(1):72–76.
  13. J. van Overbeeke, B. Hillen, and C. A. F. Tulleken. A comparative study of the circle of Willis in fetal an adult life.The configuration of the posterior bifurcation of the posterior communicating artery. Journal of Anatomy 1991;176:45–54.
  14. E. Stehbens. Aneurysms and anatomical variation of the cerebral arteries. Archives of Pathology 1963;75:45-63.
  15. Kim GE, Cho YP, Lim SM. The anatomy of the circle of Willis as predictive factor for intra-operative cerebral ischemia (shunt need) during carotid end arterectomy. Neurol Res 2002;24:237-40.
  16. Papantchev V, Hristov S, Todorova D, Naydenov E, Poloff A, Nikolov D, et al. Some variations of circle of Willis, important for cerebral protection in aortic surgery: a study in eastern Europeans. Eur J Cardiothorac Surg 2007;31:982-9.
  17. Tsutsumi M, Aikawa H, Onizuka M, Kodama T, Nii K, Matsubara S, et al. Neuroradiology 2008;50:509-18.
  18. Windle BCA. On the arteries forming circle of willis. Anat and Phy. 1888;22:289.
  19. Fawcett E, Blachford JV. The circle of Willis. An examination of specimens. J Anat and Physiol. 1905;40:63-70.
  20. Baptista AG. Studies on arteries of the brain. The anterior cerebral artery. Some anatomic features and their clinical implication. Neurology 1963;13:825-835.
  21. Nordon DG and Rodrigues Junior OF. Variations in the brain circulation – the circle of Willis. J. Morphol. Sci. 2012;29:4:243-247.
  22. Morris PP. Cerebral vascular anatomy. Neuroimaging Clinics of North America. 1996; 6:3:541-550.
  23. Perlmutter D, Rhoton AL. Jr. Microsurgical anatomy of the anterior cerebral artery- anterior communicating artery- recurrent artery complex. JNeurosurg 1976; 45(3):259-72.
  24. Puchades-Orts, A., Nombela-Gomez, M. and Ortuno- Pacheco, G. Variation in form of circle of Willis: Some anatomical and embryological considerations. Ana- tomical Record., 1975;185:119-124. doi:10.1002/ar.1091850112
  25. Rhoton Jr., A.L. The supratentorial arteries. Neu- rosurgery, 2002;51:53-120. doi:10.1097/00006123-200210001-00003.
  26. Padget, D.H. The development of the cranial ar- teries in the human embryo. Contribution to embryology. Carnegie Institution. 1948;32:205-261.
  27. Kapoor K, Singh B, Dewan I. Variations in the configuration of the circle of Willis. Anatomical Science International. 2008;83:96-106.
  28. Malamateniou C, Adams ME, Srinivasan L, Allsop JM, Counsell SJ, Cowan FM, et al. The anatomic variations of the circle of Willis in preterm-at-term and term-born infants: An MR angiography study at3T. AJNR Am J Neuroradiol 2009;30:1955-62.
  29. Voljevica A, Kulenović A, Kapur E, Vucković I. Angiography analysis ofvariations of the posterior segment of the circle of willis. Bosn J Basic Med Sci 2005;5:30-4.
  30. Poudel PP, Bhattarai C. Anomalous formation of the circulus arteriosus and its clinico-anatomical   Nepal Med Coll J 2010;12:72-5.
  31. De Silva KR, Silva R, Gunasekera WS, Jayesekera RW. Prevalence oftypical circle of Willis and the variation in the anterior communicating artery: A study of a Sri Lankan population. Ann Indian Acad Neurol 2009;12:157-61.
  32. Eftekhar B, Dadmehr M, Ansari S, Ghodsi M, Nazparvar B, Ketabchi E.Are the distributions of variations of circle of Willis different in different populations?-Results of an anatomical study and review of literature. BMC Neurol 2006;6:22.

Cite this article: Ajay Babu Kannabathula, Gunjan Rai, Himadri Sunam. ANATOMICAL VARIATIONS OF ANTERIOR CEREBRAL ARTERY AND ANTERIOR COMMUNICATING ARTERY: A CADAVERIC STUDY. Int J Anat Res 2017;5(2.3):3882-3890. DOI: 10.16965/ijar.2017.179