IJAR.2025.284
Type of Article: Original Research
Volume 14; Issue 1 (March 2026)
Page No.: 9445-9450
DOI: https://dx.doi.org/10.16965/ijar.2025.284
The High Sucrose Diet Effects on Expression of Bone Morphogenetic Protein-7 in the Alveolar Rats’ Extraction Socket: Immunohistochemical Study
Christian Khoswanto *1, Ira Kusuma Dewi 2.
*1 Department of Oral Biology Faculty of Dentistry, Airlangga University Surabaya-Indonesia.
2 Dentistry Clinic Research, Surabaya-Indonesia.
Corresponding Author: Assoc. Prof. Christian Khoswanto, DDS, MS., PhD c/o: Department of Oral Biology Faculty of Dentistry, Airlangga University. Jln. Mayjend. Prof. Dr. Moestopo No. 47 Surabaya 60132, Indonesia. E-Mail: christiankhoswanto@hotmail.com
ABSTRACT
A crucial function of wound regeneration is the mineralization and presence of calcium compounds and minerals for the survival of bone following tooth extraction. Bone morphogenetic proteins, or BMPs, are crucial for new bone growth. BMP-7 is one BMP that is highly crucial. For the newly generated bones to be perfectly formed, they also really need high-quality minerals. Among the numerous factors that can influence post-extraction healing, nutrition plays a central role. Adequate dietary intake of macronutrients and micronutrients is essential for sustaining tissue repair, angiogenesis, and bone remodeling. A high-sucrose diet can accelerate the loss of mineral-rich bone, and osteoclast resorption of alveolar bone can also raise calcium levels in plasma and urine. This study aims to investigate BMP-7 expression in Wistar rats that have undergone tooth extraction following a high-sucrose diet. ANOVA test was used to statistically analyze the outcomes. On days 10, there was a significant difference in BMP-7 expression compared to the control group.
Keywords: Extraction Socket, High Diet Sucrose, BMP-7, wound healing.
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