Type of Article:  Original Research

Volume 7; Issue 3.2 (August 2019)

Page No.: 6871-6876

DOI: https://dx.doi.org/10.16965/ijar.2019.247


Gayatri. N *1, K.K.Chaitanya 2.

*1 Associate Professor of Anatomy, MNR Medical College and Hospital, Sangareddy, Telangana, India.

2 Assistant Professor of Anatomy, MNR Medical College and Hospital, Sangareddy, Telangana, India.

Address for Correspondence: Dr.Gayatri. N, Associate Professor of Anatomy, MNR Medical College and Hospital, Sangareddy-502294, Telangana, India. Mobile no.: +919866084854. E-Mail: drgayatri1884@gmail.com


Background: Neural tube defects (NTDs) are the most common birth defects which mainly affect developing foetuses, with a high incidence rate in India and main causes of it been nutritional deficiencies and genetic predisposition. Folic acid supplementation brought decline in the incidence of NTDs.

Materials: This study was conducted on 1000 dead foetuses in Anatomy department, over a period of two years from 2017- 2019 .The dead foetuses were brought from the gynaecology and obstetrics department. A proper family history and obstetrics history was collected. The foetuses were embalmed and later studied for NTDs in detail.

Conclusion: Comparing the results with the previous studies it is clearly evident that the incidence of NTDs have significantly reduced from 11.42/1000 births to 0.2 to 10/1000 births. In most of the previous studies NTDs had a female preponderance whereas in present study there is equal preponderance. In older studies, Spina bifida was the most common NTDs followed by anencephaly. But in the present study it is the same. Incidence of NTDs has reduced due to various reasons like prenatal screening tests forfoetal anomalies and folic acid supplementation.

KEY WORDS: neural tube defects, spina bifida, neuralation, ultrasonography, karyotype.


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Cite this article: Gayatri. N, K.K.Chaitanya. RADIOLOGICAL AND GENETIC EXPRESSION OF NEURAL TUBE DEFECTS. Int J Anat Res 2019;7(3.2):6871-6876. DOI: 10.16965/ijar.2019.247