https://www.ijmhr.org/ijar.htm editor_anatomy@ijmhr.org
ISSN:       2321-4281 (E) 2321-8967 (P)

IJAR.2018.412

DOWNLOAD PDF
Table of Contents

Type of Article:  Original Research

Volume 7; Issue 1.1 (January 2019)

Page No.: 6083-6088

DOI: https://dx.doi.org/10.16965/ijar.2018.412

HISTOPATHOLOGICAL COMPARISON BETWEEN VARIOUS NORMAL AND NEUROFIBROMATOSIS TISSUE: A CADAVARIC STUDY

M. Sasirekha 1, J. Leonoline Ebenezer *2.

1 Professor and Head, Department of Anatomy, A.C.S Medical College and Hospital,   Dr.MGR Educational and Research Institute(Deemed to be University), Chennai, India.

*2 Tutor, Department of Anatomy, A.C.S Medical College and Hospital, Dr.MGR Educational and Research Institute(Deemed to be University), Chennai, India. 

Corresponding Author: Dr. J. Leonoline Ebenezer, Tutor, Department of Anatomy, A.C.S Medical College and Hospital, Dr.MGR Educational and Research Institute (Deemed to be University), Chennai-77. E-Mail: leonoline.j@gmail.com

ABSTRACT:

Background: Neurofibromatosis is a genetic disorder causing disfigurement of an individual and various organ involvements. Neurofibromatosis is one of the benign tumours affecting the peripheral nerves. With this concept in mind a cadaveric study has been done to bring out the histopathological findings in various tissues from neurofibromatosis cadaver and normal cadaver to rule out abnormalities in various tissues of the body.

Context and purpose of the study: Various tissues like skin, muscle, nerve, bone and liver were taken from neurofibromatosis cadavers and normal cadavers. Histopathological comparison was done between the various tissues. This study was done to find whether other tissues in the body of neurofibromatosis cadaver will be affected by the tumour or not?

Results: Only the skin of the neurofibromatosis cadaver showed variation .The other tissues like muscle, nerve, bone and liver from neurofibromatosis cadaver did not show any abnormal findings when compared to the normal cadaveric tissues.

Conclusions: In the present study skin of the Neurofibromatosis cadaver showed variation when compared to the normal cadaveric skin .All other tissues showed no abnormality.

Key words: Neurofibromatosis, benign tumours, cadaveric.

REFERENCES

    1. Jouhilahti EM, Peltonen S, Heape AM, et al. The pathoetiology of neurofibromatosis1. Am J Pathol 2011;178:1932–39.
    1. “Neurofibromatosis”. NHS Choices. NHS. Archived from the original on 25 September 2015. Retrieved 9 October 2015.
    1. “Neurofibromatosis Fact Sheet”. NINDS. 3 February 2016. Archived from the original on 23 January 2018. Retrieved 16 April 2018.
    1. “Learning about Neurofibromatosis”. National Human Genome Research Institute (NHGRI). 16 August 2016. Archived from the original on 10 October 2016. Retrieved 7 November 2016.
    1. Choices, NHS. “Neurofibromatosis type 1 – Treatment – NHS Choices”. www.nhs.uk. Archived from the original on 26 September 2015. Retrieved 2015-10-11.
    1. Gajeski BL, Kettner NW, Awwad EE, et al. Neurofibromatosis type I: clinical and imaging features of Von Recklinghausen’s disease. J Manipulative Physiol Ther2003;26:116–27.
    1. Reynolds RM, Browning GG, Nawroz I, et al. Von Recklinghausen’s neurofibromatosis: neurofibromatosis type 1. Lancet 2003;361:1552–4.
    1. Crawford AH, Herrera-Soto J. Scoliosis associated with neurofibromatosis. Orthop Clin North Am2007;38:553–62.
    1. Conference statement. National Institutes of Health Consensus Development Conference. Arch Neurol. 45:575–578. 1988.
    1. Neurofibromatosis type I associated with pheochromocytoma and gastrointestinal stromal tumors –A case report and literature review, Dongfeng Pan, Peifeng Liang ,Hongyan Xiao , Oncology letters, June 1, 2016, 637-643.
    1. Blakely P, Louis DN, Short MP, MacCollin M. A clinical study of patients with multiple isolated neurofibromas. J Med Genet. 2001;38(7):485–8.
    1. Jones RG, Kiatisevi P, Morris DC, Munk PL, Clarkson PW, Masri BA. Intravascular embolisation and surgical resection ofa giant neurofibroma with intratumoural haemorrhage. Br J Radiol. 2010;83(995):e225–9.
    1. Corbellini C, Vingiani A, Maffini F, Chiappa A, Bertani E, Andreoni B. Retroperitoneal pararenal isolated neurofibroma: report of a case and review of literature. Ecancermedicalscience. 2012;6:253.
    1. Longo DL, Kasper DL, Jameson JL, Fauci AS, Hauser SL, Loscalzo J. Harrison’s principles of internal medicine. 18th ed. New York: McGraw-Hill; 2012.
    1. White AK, Smith RJ, Bigler CR, Brooke WF, Schauer PR, et al. (1986) Head and neck manifestations of neurofibromatosis. Laryngoscope 96: 732-737.
    1. Bekisz O, Darimont F, Rompen EH. Diffuse but unilateral gingival enlargement associated with von Recklinghausen neurofibromatosis: A case report. J Clin Periodontol. 2000;27:361–5.
    1. Gorlin RJ, Cohen MM, Levin LF. Syndromes of the head and neck.Oxford: Oxford University Press; 1990. pp. 353–416.
    1. Posterolateral approach in a neurofibromatosis type-I patient with severe dystrophic thoracic kyphoscoliosis: A case report, cadaver study, and literature review, Bamps S 1, Calenbergh FV 1 , Loon JV 1 , Paesschen RV 2 , Vanderschot P 3  , Journal of Neurosciences in Rural Practice [01 Jan 2015, 6(1):84-86]
    1. Endo H, Utani A, Masumaoto F, Kusoki T, Yoshimoto S, Ichinose M, Shinkai H. A possible paracrine hedgehog signalling pathway in neurofibromas from patients with neurofibromatosis 1. Br J Dermatol2002;148:337–41.
    1. Neurofibromatous neuropathy in neurofibromatosis 1 (NF1) R E Ferner, R A C Hughes, S M Hall, M Upadhyaya, M R Johnson , J Med Genet 2004;41:837–841
  1. Assoul N, Ozil C, Bosc R, Hivelin M, Zidi M, et al.  Skin Elasticity in Neurofibromatosis Type 1: Rheological and Histological Analysis. J Clin Exp Dermatol Res 2014; 5: 213.

Cite this article: M. Sasirekha, J. Leonoline Ebenezer. HISTOPATHOLOGICAL COMPARISON BETWEEN VARIOUS NORMAL AND NEUROFIBROMATOSIS TISSUE: A CADAVARIC STUDY. Int J Anat Res 2019;7(1.1):6083-6088. DOI: 10.16965/ijar.2018.412