Type of Article:  Original Research

Volume 5; Issue 2.1 (April 2017)

Page No.: 3676-3681

DOI: https://dx.doi.org/10.16965/ijar.2017.138


Rajesh B 1, Ramesh B 2, Rajkiran Reddy B 3, Vimala devi N 4, Gayathri KB 5, Bhargav PRK *6.

1 Assistant Professor of Anatomy, Mediciti Institute of Medical Sciences, Hyderabad, India.

2 Assistant Professor of Biochemistry, Mediciti Institute of Medical Sciences, Hyderabad, India.

3 Senior Research Associate, SMART, Sunshine Hospitals, Hyderabad, India.

4 Physician Assistant and Research Scholar, Endocare Hospital, Vijayawada, India.

5 Associate Professor of Gynaecology, PSIMS, Vijayawada, India.

*6 Consultant Endocrine and Metabolic Surgeon, Endocare Hospital, Vijayawada, India.

Address of Corresponding Author: Dr. PRK Bhargav  MS, MCh, FACS, FIMSA, FAIS, Consultant Endocrine and Metabolic Surgeon, Director and Associate Professor of Endocrine Surgery, Endocare Hospital, Vijayawada, India – 520002, Phone No: +91-866-6617633; +91-9490130798

www.drbhargav.org; endoanswers@gmail.com


Inhibition of acetylcholinesterase (AChE), the metabolizing enzyme of acetylcholine is evolving as the most important therapeutic target for development of cognitive enhancers. However, AChE activity in brain has not been properly evaluated on the basis of sex. In the present study, AChE expression was investigated in different brain areas of cerebrum and cerebellum in male and female Rattus norvegicus. On comparing male and female genders, increased AChE activity was seen in cerebrum and cerebellum of female Rattus norvegicus.  However, no significant change in AChE activity was found between cerebrum and cerebellum within the same male and female. Thus it appears that sex alters AChE activity in different brain regions (G4 isoform) that may vary in male and female. Sequence analysis revealed that highest divergence was found in between male cerebrum and female cerebrum (11.9) and least divergence was found in between male cerebellum and female cerebellum (6.4) with control AChE NM_EF534897

Key Words: Acetylcholinesterase, Physiology, Invertebrates, Vertebrates, Cerebrum.


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Cite this article: Rajesh B, Ramesh B, Rajkiran Reddy B, Vimala devi N, Gayathri KB, Bhargav PRK. GENOMICS OF ACETYLCHOLINESTERASE (AChE) ENZYME AND ITS RELATED RNA CONTENT IN THE BRAIN OF RATTUS NORVEGICUS: A PROSPECTIVE STUDY. Int J Anat Res 2017;5(2.1):3676-3681. DOI: 10.16965/ijar.2017.138