Type of Article:  Original Research

Volume 5; Issue 1 (March 2017)

Page No.: 3629-3633

DOI: https://dx.doi.org/10.16965/ijar.2017.125


Savithri Krishnan *1, Aleyamma Fenn 2.

*1 Professor in Anatomy, Govt Medical College, Kollam, Kerala, India.

2 Professor in Anatomy, Govt Medical College, Palaghat, Kerala, India.

Corresponding Author: Dr Savithri Krishnan, Professor in Anatomy, Govt Medical College, Kollam, Kerala, India.Tel No: 09495994490 E-Mail: drsachi@gmail.com


Back ground and Purpose: The human pituitary gland, also called the endocrine band master, has three parts- the pars anterior, intermedia and nervosa. The pars intermedia is the least explored part of the endocrine bandmaster. The present study aims to demonstrate the basophilic cells of the human pituitary pars intermedia at various ages of life.

Materials and Methods: From postmortem and fetal autopsies 83 specimens of the pituitary gland were collected. These included specimens from fetuses above 18weeks of gestation to that of an 80 year old man.  After routine histological processing, the slides were subjected to histological and histochemical staining methods.

Results: Basophils formed the majority of cells in the pars intermedia of the pituitary. These basophils contained mucoproteins and ACTH/MSH granules as revealed by histochemical staining methods. The basophils invaded the pars nervosa and this basophilic invasion increased as age advanced. These invading cells were similar to the basophils in pars intermedia. They also contained mucoproteins and ACTH/MSH granules in the cytoplasm.

Conclusion: The basophils of pars intermedia invaded pars nervosa as age advanced. These basophilic cells contained ACTH/MSH granules in their cytoplasm. This basophilic invasion with increasing age is purely a physiologic phenomenon as evidenced by the increasing pigmentation with age.

Key words: ACTH/MSH granules, Basophils, Basophilic invasion, Pars intermedia.


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Cite this article: Savithri Krishnan, Aleyamma Fenn. BASOPHILS OF HUMAN PITUITARY PARS INTERMEDIA . Int J Anat Res 2017;5(1):3629-3633. DOI: 10.16965/ijar.2017.125