International Journal of Physiotherapy and Research

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Type of Article : Original Research

Year: 2016 | Volume 4 | Issue 1 | Page No. 1365-1369

Date of Publication: 11-02-2016

DOI: 10.16965/ijpr.2016.101


Dhargave Pradnya * 1, Atchayaram Nalini 2, Meghana Adoor 3, Raghuram Nagarathna 4, Trichur R. Raju 5, Kandhavelu Thennarasu 6, Talakad N. Sathyaprabha 7.

*1 Senior Physiotherapist, Physiotherapy section, NIMHANS, Bangalore, Karnataka, India.
2 Additional Professor, Department of Neurology, NIMHANS, Bangalore, Karnataka, India.
3 Research Associate, Department of Neurophysiology, NIMHANS, Bangalore, Karnataka, India.
4 Dean, Yoga and Physical Science, Vivekananda Yoga Research Foundation, Bangalore, India.
5 Senior Professor, Department of Neurophysiology, NIMHANS, Bangalore, Karnataka, India.
6 Professor, Department of Biostatistics, NIMHANS, Bangalore, Karnataka, India.
7 Professor, Department of Neurophysiology, NIMHANS, Bangalore, Karnataka, India.

Corresponding author: Dr. Dhargave Pradnya, PhD., (Neuro Rehab), Senior Physiotherapist, Physiotherapy section, NIMHANS, Bangalore, Karnataka, India.


Aim:  The prognosis for Duchenne Muscular Dystrophy (DMD) life depends to a large extent on the respiratory function. Inspiratory and expiratory muscles are affected and respiratory problems occur with or without spinal deformities. It is important to characterize the respiratory function in DMD to facilitate decision of timing of the intervention.
Methodology: 124 DMD male children whose parents gave written consent were recruited. The Pulmonary function tests were performed using Spirometry kit (Spiro instrument’s software) (Microquark Cosmed, Italy). The values of Forced Vital Capacity (FVC), Peak Expiratory Flow (PEF) and Peak Inspiratory Flow (PIF), Tidal Volume (TV) and Maximum Voluntary Ventilation (MVV) were analyzed. These results were compared with the healthy children and correlated with semiology of the disease.
Results: One twenty four subjects with mean age at presentation were 7.9 ± 1.5 years. Mean age of onset was 2.8 ± 0.6 years (1.5 - 4.0 years). Mean duration of illness was 5.1 ± 1.5 years (1 - 8 years). The respiratory functions were poor in DMD compared to healthy controls. Age and duration of illness were positively correlated with pulmonary function.
Conclusion: Our study enlightened large number Indian DMD children’s pulmonary function parameters. Characterization of the pulmonary dysfunctions helped us in improving the quality of life in DMD children, by timely modifying the rehabilitation regime. This study also explained about the respiratory dysfunction in DMD in Indian population that can be used for choosing the suitable rehabilitation programs, targeted towards the symptomatic treatment of DMD children.
Key Words: Pulmonary function, Duchenne Muscular Dystrophy.


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Dhargave Pradnya, Atchayaram Nalini, Meghana Adoor, Raghuram Nagarathna, Trichur R. Raju, Kandhavelu Thennarasu, Talakad N. Sathyaprabha. RESPIRATORY DYSFUNCTIONS IN CHILDREN WITH DUCHENNE MUSCULAR DYSTROPHY. Int J Physiother Res 2016;4(1):1365-1369. DOI: 10.16965/ijpr.2016.101




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