Type of Article: Original Research
Year: 2016 | Volume 4 | Issue 2 | Page No. 2412-2415
Date of Publication: 30-06-2016
IDENTIFICATION OF MICRONUCLEUS IN BUCCAL MUCOSA OF TYPE -2 DIABETIC PATIENTS: AN EARLY DIAGNOSTIC MARKER
Ashwin Singh J *1, M.Jayasabarinathan 2, Sheela Grace Jeevamani 3.
*1 Pre final yearMBBS Student, Karpagam Faculty of Medical Sciences and Research, Coimbatore, Tamilnadu, India.
2 Associate Professor, Department of Anatomy, Karpagam Faculty of Medical Sciences and Research, Coimbatore, Tamilnadu, India.
3 Professor, Department of Anatomy, Karpagam Faculty of Medical Sciences and Research, Coimbatore, Tamilnadu, India.
Address: Mr. Ashwin Singh. J, Pre final year MBBS Student, Karpagam Faculty of Medical Sciences and Research, Othakkalmandabam, Coimbatore – 641028, Tamilnadu, India.
Background and Aims: The elevated levels of DNA damage, decreased efficacy of DNA repair and high susceptibility to mutagens have been associated with type 2 diabetes mellitus. The Micronucleus (MN) is a condensed form of chromatin with the appearance of small nuclei present in the cytoplasm and it is formed from chromosomal fragments or intact whole chromosomes that lag behind at the anaphase stage of cell division. So the presence of MN in cells reflect structural and numerical chromosomal aberrations arising during mitosis.
Materials and Methods: In the present study 50 cases of diabetic patients and 50 non diabetic patients were taken for screening for Micronuclei (MN).
Results: In diabetic patients, the frequency of micronuclei were more than the control group. So it is significantly elevated in type 2 diabetes patients. This is due to the elevated level of DNA damage in these patients.
Conclusion: The presence of micronuclei indicates the genomic instability and chromosomal damage. This can be a predisposing factor for development of cancer. So this can be used as a biomarker for diagnosis of type 2 diabetes mellitus.
Key Words: Micronucleus, Buccal Mucosa, Type -2 Diabetic Patients.
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Ashwin Singh J, M.Jayasabarinathan, Sheela Grace Jeevamani. IDENTIFICATION OF MICRONUCLEUS IN BUCCAL MUCOSA OF TYPE -2 DIABETIC PATIENTS: AN EARLY DIAGNOSTIC MARKER. Int J Anat Res 2016;4(2):2412-2415. DOI: 10.16965/ijar.2016.219