Type of Article: Original Research
Year: 2016 | Volume 4 | Issue 2 | Page No. 2358-2364
Date of Publication: 31-05-2016
TERATOLOGICAL EFFECTS OF CARBOPLATIN: A MORPHOLOGICAL STUDY IN MICE
Vivek Parashar *1, Buddhadeb Ghosh 2, Natwar lal Gaur 3, Satya Narayan Shamal 4, S K Pandey 5, Girdhari Lal Shah 6.
1 Assistant Professor, K D Medical College Hospital and Research Centre, Mathura, Uttar Pradesh, India.
2 Assistant Professor, K D Medical College Hospital and Research Centre, Mathura, Uttar Pradesh, India.
3 Tutor, K D Medical College Hospital and Research Centre, Mathura, Uttar Pradesh, India.
4 Professor, Institute of Medical Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
5 Professor, Institute of Medical Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
6 Professor, Institute of Medical Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Address: Dr.Vivek Parashar, Assistant Professor, Dept of Anatomy, K D Medical College Hospital and Research Centre, Mathura, Uttar Pradesh, India.
Background: Carboplatin (cis-diammine 1, 1cyclobutanedi carboxylateplatinumII), is an antitumor platinum complex derived from cisplatin. Preclinical studies suggest that it may have greater antitumor activity and lower toxicity than cisplatin. The potential of Carboplatin to induce embryo toxicity was investigated in the albino mice.
Materials and Methods: Fourty pregnant mice were distributed among treated [ n=30 ] and a control [ n=10 ] group. Carboplatin was administered intraperitoneally to pregnant mice of treated group on day 7th of gestation at dose level of 6 mg/kg. All dams were subjected to caesarean section on Day 19 of gestation under deep anesthesia according to the animal ethical guidelines.
Result: At given dose an increase in the resorption rate and a reduction in the fetal weight and height were found. Gross malformations obsereved were intraperitoneal hemorrhage, increased neck bending and limb hemorrhage. There were no signs of maternal toxicity.
Conclusion: The results show that carboplatin is embryotoxic at minimally maternal toxic dose in mice.
Key Words: Teratology, Carboplatin, Abortion, Haemorrhage, Mice, Anomaly.
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Vivek Parashar, Buddhadeb Ghosh, Natwar lal Gaur, Satya Narayan Shamal, S K Pandey, Girdhari Lal Shah. TERATOLOGICAL EFFECTS OF CARBOPLATIN: A MORPHOLOGICAL STUDY IN MICE. Int J Anat Res 2016;4(2):2358-2364. DOI: 10.16965/ijar.2016.218