Type of Article: Original Research
Year: 2016 | Volume 4 | Issue 2 | Page No. 2337-2341
Date of Publication: 31-05-2016
CHROMOSOMAL TRANSLOCATIONS IN ACUTE LYMPHOBLASTIC LEUKEMIA IN NORTH INDIAN POPULATION
Indushri 1, Archana Rani *2, Rakesh Kumar Verma 2, Navneet Kumar 2 .,
1 Department of Anatomy, Maharaja Ganga Singh Dental College, Sri Ganganagar, Rajasthan, India.
*2Department of Anatomy, King George’s Medical University, Lucknow, Uttar Pradesh, India.
Address: Dr. Archana Rani, MD, Professor, Department of Anatomy, King George’s Medical University, Lucknow- 226003 Uttar Pradesh, India.
Introduction: Recurrent chromosomal abnormalities in the malignant cells of patients with acute leukemia are hallmark of the disease. Specific aberrations, which are frequently indicative of consistent underlying molecular lesions, can assist or even establish the diagnosis and determine optimal therapy.
Materials and methods: Karyograms of 51 North Indian patients (44 males and 7 females) of acute lymphoblastic leukemia (ALL) from the age group of 2 to 42 years were prepared and observed for the various chromosomal translocations and their frequency.
Results: Out of total thirty nine analyzed cases, translocation was detected in thirteen cases (33.33%), most frequent chromosomal translocation was t (9;22) being detected in 4 cases (10.25 %), t (4;11) in three cases (7.69%) and one case (2.56%) each was found with t (8;21), t (1;3), t (8;14), t (1;8), t (1;19), t (4;12), t (3;19). There was random distribution of various chromosomal translocations in different age group and sex.
Conclusion: The unique finding of the present study was reporting of t (8;21), t (1;8), t (4;12) and t (3;19), each with one case which was not observed previously by any author in acute lymphoblastic leukemia in North Indians. The findings of the present study may be useful for pediatricians and physicians in predicting outcome, remission, survival and treatment response in acute lymphoblastic leukemia (ALL).
Key Words: Acute lymphoblastic leukemia, p-arm, q-arm,Translocation.
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Indushri, Archana Rani, Rakesh Kumar Verma, Navneet Kumar. CHROMOSOMAL TRANSLOCATIONS IN ACUTE LYMPHOBLASTIC LEUKEMIA IN NORTH INDIAN POPULATION. Int J Anat Res 2016;4(2):2269-2272. DOI: 10.16965/ijar.2016.211