International Journal of Anatomy and Research

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Type of Article: Original Research

Year: 2016 | Volume 4 | Issue 1 | Page No. 2119-2124

Date of Publication: 31-03-2016



Rajeev Mukhia *1, Aruna Mukherjee 2, Anjali Sabnis 3.

*1 Ph.D Scholar, Anatomy Department, MGM Medical College, Navi Mumbai, India.
2 Professor and Head, Anatomy Department, MGM Medical College, Navi Mumbai, India.
3 Professor of Anatomy, MGM Medical College, Kamothe Navi Mumbai, India.

Address: Mr. Rajeev Mukhia, Ph.D Scholar, Anatomy Department, MGM Medical College, Navi Mumbai, Maharashtra, India.


Introduction: Spleen is the organ of interest for research workers since a long time. Though, detailed study about embryonic development is there in the literature but microscopic structures of spleen at different stages in the fetal period is far less available. Hence, the present study attempted to find out the detailed histological changes of human fetal spleen during its development.
Materials and Methods: The study was carried out on 50 human foetuses of known gestational age in the department of Anatomy, MGM Medical College, Navi Mumbai. The sections of the spleen were studied after staining with Haematoxylin and Eosin stain and were observed under compound light microscope.
Observations and Results: At 12-14th gestational week of development there was irregular network of mescenchymal cells with thin capsule, reticular cells; lymphoblast’s and few blood vessels were present. Increased haematopoietic cells including WBC’s and RBC’s were seen at 15th week. Vascularity increased at 16-17th week. At 18th week the tissue started showing division of red pulp and white pulp. Clear-cut division was seen after 20th week stage.  From 22nd weeks onwards the structure was almost similar to that of adult spleen. Germinal centre was not seen up to 38th week of gestation.
Conclusion: The study provides a detailed knowledge about the histogenesis of human fetal spleen. It also suggests the functional status of spleen in fetal period.
KEY WORDS: Spleen, Histogenesis, White pulp, Red pulp, Reticular cells.


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Rajeev Mukhia, Aruna Mukherjee, Anjali Sabnis. HISTOGENESIS OF HUMAN FETAL SPLEEN. Int J Anat Res 2016;4(1):2119-2124. DOI: 10.16965/ijar.2016.159




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