International Journal of Anatomy and Research

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Type of Article: Original Research

Year: 2016 | Volume 4 | Issue 1 | Page No. 1945-1953

Date of Publication: 29-02-2016



Ashraf Mohamed Elsayed Ali SAKRAN *1, Hassan Elsiddig Hassan Faragalla 2,3, Asim Y. Ibrahim 4, Abdullah Galil Alkushi 5, Anil Kumar Chhotalal Mithani 6, Muawia Abdel magidElsadig khalafalla 7.

*1 Department of Human Anatomy, Faculty of Medicine, Umm al Qura University, Saudi Arabia.
2 Department of Public Health, Health Sciences College at Al.lith, Umm al Qura University, Saudi Arabia.
3 Department of Histopathology and Cytology, Faculty of Medical Laboratory Science, Sudan University of Science and Technology, Khartoum, Sudan.
4 Department of Pharmaceutics, Faculty of Pharmacy, Umm al Qura University, Saudi Arabia.
5 Department of Human Anatomy, Faculty of Medicine, Umm al Qura University, Saudi Arabia.
6 Department of Surgery, College of Medicine, University of Bahri, Sudan.
7 College of Computer Science and Technology, Sudan University of Science and Technology, Sudan.

Address: Dr. Ashraf M. E. A. Sakran, Department of Human Anatomy, Faculty of Medicine, Umm al Qura University, P.O. Box: 7607, Makkah, Saudi Arabia. Phone: 00966568841873 or 00249912254379


Background and objective: The Fenugreek seeds effect on vagina rat's estrous andits galactogogualactivity were suggested to their estrogen and/or progesterone like action. Accordingly, this study is concerning with the role of  different doses of Fenugreek seeds, that may play, on mature,perimature immature rat's ovary.
Materials and Methords: A total of 135, healthy virgin female Norway albino rats were used for the study. Fenugreek seeds were administrated by oro-gastric tube to the experimental rats. The rats were divided according to their age into three groups, namely, mature,perimature and immature. Each group was subdivided into subgroups according to the dose of Fenugreek seeds (0.8, 1.6 and 3.2 mg/g bod weight) used. Ovaries of these rats were processed for histological study.
Results: This study showed an increase on ovarian size of all experimental subgroups, compared with control groups. Histological study of the ovaries revealed  marked increase in the mean number of all types of growing follicles (folliculogenisis) and the total structures in the ovaries. The increase in the thickness of theca interna was prominentin all experimental subgroups.
Conclusion: The data obtained from this study elicit that crude Fenugreek seeds possess estrogen like action which can be performed by their direct action or through diosgenin biotransformation to estrogen inside the ovary. This estrogen enhance folliculogenisis indirectly. The histological findings of mature, Perimature and immature  rats treated with Fenugreek seeds was nearly identical, irrespective of the doses used in this study.   
Key Words: Fenugreek Seeds, Ovary, Histology, Estrogen And Progesterone Hormones.


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Ashraf Mohamed Elsayed Ali SAKRAN, Hassan Elsiddig Hassan Faragalla, Asim Y. Ibrahim, Abdullah Galil Alkushi, Anil KumarChhotalalMithani, Muawia Abdel magidElsadig khalafalla. EFFECT OF FENUGREEK SEEDS ON RAT'S OVARY: HISTOLOGICAL STUDY. Int J Anat Res 2016;4(1):1945-1953. DOI: 10.16965/ijar.2016.118




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