Type of Article: Original Research
Year: 2016 | Volume 4 | Issue 1 | Page No. 1896-1900
Date of Publication: 29-02-2016
MORPHOLOGICAL AND HISTOPATHOLOGICAL STUDY OF PLACENTA IN CHILDREN WITH AND WITHOUT HYPOSPADIAS
Bindhu. S *1, Meera Jacob 2, R. B. Nerli 3, R K Avadhani 4.
*1 Associate Professor, Department of Anatomy, Yenepoya Medical College, Yenepoya University, Mangalore, Karnataka, India.
2 Assistant Professor,Department of Anatomy, Yenepoya Medical College, Yenepoya University, Mangalore, Karnataka, India.
3 Professor & HOD, Department of Urology, KLE’s Prabhakar Kore hospital, KLE University, Belgaum, Karnataka, India.
4 Professor & HOD, Department of Anatomy, Yenepoya Medical College, Yenepoya University, Mangalore, Karnataka, India.
Address: Dr. Bindhu.S, Department of Anatomy, Yenepoya Medical College, Deralakatte, Mangalore, Karnataka, India- 575018.
Introduction: Hypospadias is one of the most common congenital anomaly of male external genitalia. It occurs in approximately 1 in 250 new born. Hypospadias can be defined as an abnormal urethral orifice under surface of the penis with or without chordee and with or without dorsal hood. Hypospadias may be an isolated defect or a phenotypical component of a more complex condition such as an intersex state.
Aim: This study aimed to observe and document morphological and histopathological changes of placenta in children with hypospadias and compare with controls.
Materials and Methods: The present study was a case control study and the data base of the labor registries of the hospital indicated that there were total 3243 male births during this period. All examined for presence /absence of hypospadias by attending pediatrician. Hypospadias was detected in 17 male newborns. Control cases comprised of 68 male newborns without hypospadias of similar gestational age and birth weight collected by cluster sampling. The placenta was collected and examined for placental weight, thickness, and histopathology.
Results and Conclusion: Total number of male birth during the study period was 3243, in that17 children born with hypospadias. The incidence of hypospadias in our hospital was 0.52%, Histopathological study revealed excessive syncytial knots formation, infarction, calcification, thickening of basement membrane, stromal fibrosis, villous oedema, and hemorrhage. But the values were similar in children with hypospadias when compared with controls.
Conclusion: This study shows placental insufficiency is not associated with hypospadias.
Key words: Hypospadias , Placenta, Infarct, Syncytial Knot.
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Bindhu. S, Meera Jacob, R. B. Nerli, R K Avadhani. MORPHOLOGICAL AND HISTOPATHOLOGICAL STUDY OF PLACENTA IN CHILDREN WITH AND WITHOUT HYPOSPADIAS. Int J Anat Res 2016;4(1):1896-1900. DOI: 10.16965/ijar.2016.106