International Journal of Anatomy and Research



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Type of Article: Original Research

Year: 2016 | Volume 4 | Issue 1 | Page No. 1896-1900

Date of Publication: 29-02-2016

DOI: http://dx.doi.org/10.16965/ijar.2016.106


MORPHOLOGICAL AND HISTOPATHOLOGICAL STUDY OF PLACENTA IN CHILDREN WITH AND WITHOUT HYPOSPADIAS

Bindhu. S *1, Meera Jacob 2, R. B. Nerli 3, R K Avadhani 4.

*1 Associate Professor, Department of Anatomy, Yenepoya Medical College, Yenepoya University, Mangalore, Karnataka, India.
2 Assistant Professor,Department of Anatomy, Yenepoya Medical College, Yenepoya University, Mangalore, Karnataka, India.
3 Professor & HOD, Department of Urology, KLE’s Prabhakar Kore hospital, KLE University, Belgaum, Karnataka, India.
4 Professor & HOD, Department of Anatomy, Yenepoya Medical College, Yenepoya University, Mangalore, Karnataka, India.

Address: Dr. Bindhu.S, Department of Anatomy, Yenepoya Medical College, Deralakatte, Mangalore, Karnataka, India- 575018.
E-Mail: nairbindhu@yahoo.com

Abstract

Introduction: Hypospadias is one of the most common congenital anomaly of male external genitalia. It occurs in approximately 1 in 250 new born. Hypospadias can be defined as an abnormal urethral orifice under surface of the penis with or without chordee and with or without dorsal hood. Hypospadias may be an isolated defect or a phenotypical component of a more complex condition such as an intersex state.
Aim: This study aimed to observe and document morphological and histopathological changes of placenta in children with hypospadias and compare with controls.
Materials and Methods: The present study was a case control study and the data base of the labor registries of the hospital indicated that there were total 3243 male births during this period. All examined for presence /absence of hypospadias by attending pediatrician. Hypospadias was detected in 17 male newborns. Control cases comprised of 68 male newborns without hypospadias of similar gestational age and birth weight collected by cluster sampling. The placenta was collected and examined for placental weight, thickness, and histopathology.
Results and Conclusion: Total number of male birth during the study period was 3243, in that17 children born with hypospadias. The incidence of hypospadias in our hospital was 0.52%, Histopathological study revealed excessive syncytial knots formation, infarction, calcification, thickening of basement membrane, stromal fibrosis, villous oedema, and hemorrhage. But the values were similar in children with hypospadias when compared with controls.
Conclusion: This study shows placental insufficiency is not associated with hypospadias.
Key words: Hypospadias , Placenta, Infarct, Syncytial Knot.

References

  1. Paulozzi J, Erickson J D, Jackson R J. Hypospadias trends in two U S surveillance systems.Pediatrics.1997;100(5):831-834.
  2. Mouriquand PD, Persad R, Sharma S: Hypospadias repair: current principles and Procedures.Br J Urol 1995; 76(Suppl 3):9-22.
  3. Campbell MF. Campbell-Walsh Urology.9th ed. Alen.J. Wein: USA: Saunders; 2007; P.3706-3707.
  4. Hussain N, Chaghtai A, Herndon CD, et al: Hypospadias and early gestation growth restriction in infants. Pediatrics 2002; 109(3):473-478.
  5. Weidner I S, Moller H, Jensen TK, Skakkebaek NE. Risk factors of cryptorchidism and hypospadias .J Urol.1999;161:1606-1609.
  6. Aschim EL, Haugen TB, Tretli S, Daltveit AK, Grotmol T. Risk factors for hypospadias in Norwegian boys—association with testicular dysgenesis syndrome? Int J Androl. 2004;27(4):213–221.
  7. Thame M, Wilks RJ, McFarlane-Anderson N, Bennett FI & Forrester TE. Fetal growth is directly related to maternal anthropometry and placental volume. European Journal of Clinical Nutrition. 2004 ;58: 894–900.
  8. Sadler T.W. Langmann’ Medical embryology,9th edition. Baltimore, MD: Lippincott Williams and Wilkins;2004;p.117-48.
  9. Wolf H, Oosting H, Treffers P E.A longitudinal study of the relationship between placental fetal growth measured by ultrasonography. Am JObstet. Gynecol. 1989;161: 1140-45.
  10. Clappe JH, Rizk KH. Appleby –Wineberg SK, Grass JR. Second trimester placental volume predicts birth weight at term .J Soc Gynecol Investig 1995;2:19-22.
  11. Thomson , A.M, Billewicz ,W.Z, and Hytten, F.E.J. Obstetrics and Gynaecology of British Commonwealth1969;76:8650.
  12. Zeek P M, Assali N S. Vascular changes in the deciduas associated with eclamptogenic toxaemia of pregnancy. American journal of clinical pathology 1950; 20:1099-1109.
  13. Fox H. Pathology of placenta. 2nd ed. Virginia A. Livolsi: London: Sunders; 1997,113-118.
  14. Fugikura T, Placental calcification and maternal age. American journal of Obstetrics and Gynecology1963a;87:41-45.
  15. Naaeye, R.L, Maaisels, J; Lorenz, R.P and Botti, J.J,1983.The clinical significance placental villous edema.Pediatrics1983;71:588-594.
  16. Fox H. Basement membrane in the villi of the human placenta. Journal of obstetrics and gynecology of the British Commonwealth 1968c ;75:830-84.

 

Bindhu. S, Meera Jacob, R. B. Nerli, R K Avadhani. MORPHOLOGICAL AND HISTOPATHOLOGICAL STUDY OF PLACENTA IN CHILDREN WITH AND WITHOUT HYPOSPADIAS. Int J Anat Res 2016;4(1):1896-1900. DOI: 10.16965/ijar.2016.106

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