Type of Article: Original Research
Year: 2016 | Volume 4 | Issue 1 | Page No. 1819-1824
Date of Publication: 31-01-2016
ESTIMATION OF GLOMERULAR SIZE BY MICROMETRY IN MIDGESTATIONAL PERIOD
Suvarna A. Gulanikar *1, G.A. Shroff 2, A.R. kharkar 3, V.S.Mandhana 4.
*1 Assistant Professor, Dept. Of Anatomy, MGM Medical college, Aurangabad, Maharashtra, India.
2 Professor, Dept. Of Anatomy, MGM Medical college, Aurangabad, Maharashtra, India.
3 Professor, Dept. Of Anatomy, MGM Medical college, Aurangabad, Maharashtra, India.
4 Associate Professor, Dept. Of Anatomy, MGM Medical college, Aurangabad, Maharashtra, India.
Address: Dr. Suvarna A. Gulanikar, Assistant Professor, Dept. Of Anatomy, MGM Medical college, Aurangabad, Maharashtra, India.
Introduction: Changes in glomerular size play an important role in the initiation and progression of various glomerulopathies. There are few anatomical reports on the fetal glomerular size than on adult human renal glomerulus. Therefore, our study conducted, with an aim to estimate an average glomerular diameter in cortical zones of the kidney during 14th to the 28th weeks of gestation, to define periods of their most intensive growth, and to record differences of glomerular size between different cortical zones.
Materials and Methods: Thirty normal human fetuses without any congenital anomalies in midgestational period ranging from 14 to 28 weeks were selected for the study. The glomerular diameters were evaluated in hematoxylin and eosin-stained microscopic sections of the kidneys by micrometry in outer, middle, and inner zones of renal cortex. Average diameter was calculated in different groups and relation of them in all three zones of the cortex was analysed.
Results: The results showed that outer cortex glomerulus were smallest with the average diameter of 55.88 ±7.20 to 63.5±7.33 µm. At the deeper level, size of glomerulus increased. In the intermediate cortex average size of glomerulus is 69.85 ± 23.18 to 87.63 ± 9.37 µm. and the deepest juxta medullary glomerulus were largest in size with the average diameter of 94.61±14.18 to 117.47± 10.89 .
Conclusion: The present study concluded that smallest diameter of glomerulus was seen in outer cortex, while the largest one in inner cortex. In all the age groups [14-28 weeks] the glomerular diameter remained nearly same in each zone of the cortex. The Changes in glomerular size played an important role in the initiation and progression of various glomerulopathies. The importance of this study lies in determining the average glomerular diameter, which could be used as baseline values for studies of glomerular diseases. It may be possible to define the pathological changes in fetal kidney based on the present study.
KEY WORDS: Glomerulus, Cortex, Micrometry, Glomerulopathies.
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Suvarna A. Gulanikar, G.A. Shroff, A.R. kharkar, V.S.Mandhana. ESTIMATION OF GLOMERULAR SIZE BY MICROMETRY IN MIDGESTATIONAL PERIOD. Int J Anat Res 2016;4(1):1819-1824. DOI: 10.16965/ijar.2015.341