{"id":2905,"date":"2024-03-01T07:17:25","date_gmt":"2024-03-01T07:17:25","guid":{"rendered":"https:\/\/www.ijmhr.org\/IntJAnatRes\/?page_id=2905"},"modified":"2024-03-01T07:17:25","modified_gmt":"2024-03-01T07:17:25","slug":"ijar-2023-271","status":"publish","type":"page","link":"https:\/\/www.ijmhr.org\/IntJAnatRes\/ijar-2023-271","title":{"rendered":"IJAR.2023.271"},"content":{"rendered":"<div class=\"su-row\"><div class=\"su-column su-column-size-1-2\"><div class=\"su-column-inner su-u-clearfix su-u-trim\"><div class=\"su-button-center\"><a href=\"https:\/\/www.ijmhr.org\/ijar.12.1\/IJAR.2023.271.pdf\" class=\"su-button su-button-style-default\" style=\"color:#FFFFFF;background-color:#6b0e00;border-color:#560c00;border-radius:5px;-moz-border-radius:5px;-webkit-border-radius:5px\" target=\"_self\"><span style=\"color:#FFFFFF;padding:6px 16px;font-size:13px;line-height:20px;border-color:#98574d;border-radius:5px;-moz-border-radius:5px;-webkit-border-radius:5px;text-shadow:none;-moz-text-shadow:none;-webkit-text-shadow:none\"><i class=\"sui sui-cloud-download\" style=\"font-size:13px;color:#FFFFFF\"><\/i> DOWNLOAD PDF<\/span><\/a><\/div><\/div><\/div> <div class=\"su-column su-column-size-1-2\"><div class=\"su-column-inner su-u-clearfix su-u-trim\"><div class=\"su-button-center\"><a href=\"https:\/\/ijmhr.org\/ijar-vol-12-1.htm\" class=\"su-button su-button-style-default\" style=\"color:#FFFFFF;background-color:#6b0e00;border-color:#560c00;border-radius:5px;-moz-border-radius:5px;-webkit-border-radius:5px\" target=\"_self\"><span style=\"color:#FFFFFF;padding:6px 16px;font-size:13px;line-height:20px;border-color:#98574d;border-radius:5px;-moz-border-radius:5px;-webkit-border-radius:5px;text-shadow:none;-moz-text-shadow:none;-webkit-text-shadow:none\"><i class=\"sui sui-book\" style=\"font-size:13px;color:#FFFFFF\"><\/i> Table of Contents<\/span><\/a><\/div><\/div><\/div><\/div>\n<h3 style=\"text-align: justify;\"><strong>Type of Article:<\/strong> \u00a0Original Research<\/h3>\n<h3 style=\"text-align: justify;\"><strong>Volume 12; Issue 1 (March 2024)<\/strong><\/h3>\n<h3 style=\"text-align: justify;\"><strong>Page No.:<\/strong> 8855-8861<\/h3>\n<h3 style=\"text-align: justify;\"><strong>DOI:\u00a0<\/strong>https:\/\/dx.doi.org\/10.16965\/ijar.2023.271<\/h3>\n<h3 style=\"text-align: justify;\">Anatomical Considerations for Placing Spinal Cord Stimulators in Patients with Coronary Vascular Disease and Cardiomegaly<\/h3>\n<p><strong>Cheryl Melovitz-Vasan *<sup>1<\/sup>, Susan Huff <sup>2<\/sup>, Nagaswami Vasan <sup>3<\/sup>.<\/strong><\/p>\n<p style=\"text-align: justify;\"><sup>1<\/sup> Associate Professor, Department of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, 08103.New Jersey, USA.\u00a0<\/p>\n<p style=\"text-align: justify;\"><sup>2 <\/sup>Medical Education Research Collaborator; Rowan University Division of Global Learning and Partnerships, Glassboro, New Jersey, USA. <strong>ORCiD: <\/strong>0009-0002-7265-6773<\/p>\n<p style=\"text-align: justify;\"><sup>3 <\/sup>Professor of Anatomy Department of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, New Jersey 08103, USA. <strong>ORCiD: <\/strong>0000-0002-3853-7263<\/p>\n<p style=\"text-align: justify;\"><strong>Corresponding Author: \u00a0<\/strong>Cheryl Melovitz-Vasan, PT., DPT., Ph.D., Associate Professor. Department of Biomedical Sciences, Cooper Medical School of Rowan University, 401 South Broadway, Camden, New Jersey 08103, USA. Phone: 1-856-361-2889.\u00a0<strong>E-Mail:<\/strong> Melovitz-Vasan@rowan.edu<\/p>\n<p style=\"text-align: justify;\"><strong>ABSTRACT<\/strong>\u00a0<\/p>\n<p style=\"text-align: justify;\"><strong>Background:<\/strong> The Spinal Column Stimulator (SCS) of the dorsal columns was first used in 1967 as a nonpharmacologic option for treating chronic intractable cancer pain.\u00a0 It works by blocking pain signals before they reach the brain.\u00a0 The device sends electrical pulses to electrodes placed over the spinal cord.\u00a0 These pulses modify the pain signals, which either make them imperceptible or replace them with a tingling sensation.\u00a0 It is important to note that spinal cord stimulation does not eliminate the source of pain, but rather changes how the brain perceives it.\u00a0 The placement of the electrode leads varies depending on the conditions being treated.\u00a0 SCS has become widely used both as an effective and practical option for the management of refractory chronic pain that is unresponsive to conventional treatments.\u00a0\u00a0\u00a0<\/p>\n<p style=\"text-align: justify;\"><strong>Results:<\/strong> While medical students were dissecting the body of a 91-year-old male donor who died of atherosclerotic coronary vascular disease and cardiomegaly, they encountered an implanted SCS device.\u00a0 Further dissection showed electrodes from the pulse generator reaching midthoracic level; the anodes and cathode leads were in the dorsal epidural space.\u00a0 The fact that the leads were in the midthoracic region and the donor had chronic atherosclerotic coronary vascular disease and cardiomegaly, he was probably treated for pain related to his cardiac conditions (refractory angina pectoris).<\/p>\n<p style=\"text-align: justify;\"><strong>Conclusions:<\/strong> In the SCS procedure, numerous anatomical structures within the spinal canal, such as the fatty tissue inside the epidural space, membranes of the dural sac, cerebrospinal fluid (CSF), and spinal cord nerve roots and rootlets, could affect the outcome for the patient.<\/p>\n<p style=\"text-align: justify;\"><strong>Keywords:<\/strong> Spinal Cord Stimulators, Anatomy of the spinal canal, Treating chronic intractable pain, Neural mechanism of pain perception.<\/p>\n<p style=\"text-align: justify;\"><strong>REFERENCES<\/strong><\/p>\n<p style=\"text-align: justify;\">[1]. Shealy CN, Mortimer JT, Reswick JB. Electrical inhibition of pain by stimulation of the dorsal columns: preliminary clinical report. Anesth Analg 1967; 46:489-491. <br \/>https:\/\/doi.org\/10.1213\/00000539-196707000-00025<br \/>[2]. Jeon YH. Spinal cord stimulation in pain management: a review. Korean J Pain 2012; 25:143-150. <br \/>https:\/\/doi.org\/10.3344\/kjp.2012.25.3.143<br \/>PMid:22787543 PMCid:PMC3389317<br \/>[3]. Rock AK, Truong H, Park YL, Pilitsis JG. Spinal Cord Stimulation. Neurosurg Clin N Am 2019; 30:169-194. <br \/>https:\/\/doi.org\/10.1016\/j.nec.2018.12.003<br \/>PMid:30898269<br \/>[4]. Melzack R, Wall RD. Pain mechanisms: a new theory. Science 1965; 150:971-979. <br \/>https:\/\/doi.org\/10.1126\/science.150.3699.971<br \/>PMid:5320816<br \/>[5]. Linderoth B, Foreman RD. Physiology of spinal cord stimulation: review and update. Neuromodulation 1999; 2:150-164. <br \/>https:\/\/doi.org\/10.1046\/j.1525-1403.1999.00150.x<br \/>PMid:22151202<br \/>[6]. Verrills P, Sinclair C, Barnard A. A review of spinal cord stimulation systems for chronic pain. J Pain Res 2016; 9:481-492. <br \/>https:\/\/doi.org\/10.2147\/JPR.S108884<br \/>PMid:27445503 PMCid:PMC4938148<br \/>[7]. De Andres J, Reina MA, Hernandez JM, Carrera A, Oliva A, Prats-Galino A. Role of Spinal Anatomical Structures for Neuromodulation. Regional Anesthesia and Pain Medicine 2011;36(Suppl): E130-E137. Published by BMJ Online ISSN: 1532-8651; Print ISSN: 1098-7339.<br \/>[8]. Barolat G. Experience with 509 plate electrodes implanted epidurally from C1 to L1. Stereotact Funct Neurosurg 1993; 61:60-79. <br \/>https:\/\/doi.org\/10.1159\/000100624<br \/>PMid:8197329<br \/>[9]. Jenkinson RH, Wendahl A, Zhang Y, Sindt JE. Migration of Epidural Leads During Spinal Cord Stimulator Trials. J Pain Res 2022;15:2999-3005. <br \/>https:\/\/doi.org\/10.2147\/JPR.S378937<br \/>PMid:36186754 PMCid:PMC9518680<br \/>[10]. Feirabend HKP, Choufoer H, Ploeger S, Holsheimer J, van Gool JD. Morphometry of human superficial dorsal and dorsolateral column fibers: significance to spinal cord stimulation. Brain 2002; 125:1137-1149. <br \/>https:\/\/doi.org\/10.1093\/brain\/awf111<br \/>PMid:11960902<br \/>[11]. Spinal Cord Stimulator [Internet]. Baltimore: The Johns Hopkins University, The Johns Hopkins Hospital, and Johns Hopkins Health System; c2023 [cited 2023 Nov 10]. Available from: https:\/\/www.hopkinsmedicine.org\/health\/treatment-tests-and-therapies\/treating-pain-with-spinal-cord-stimulators.<br \/>[12]. Reina MA, Pulido P, Castedo J, Villanueva MC, Lopez A, Sola RG. Characteristics and distribution of normal human epidural fat. Rev Esp Anestesiol Reanim 2006; 53:363-372. PMID: 16910144. [In Spanish][13]. Reina MA, Franco CD, Lopez A, De Andres JA, van Zundert A. Clinical implications of epidural fat in the spinal canal. A scanning electron microscopic study. Acta Anaesthesiol Belg 2009; 60:7-17. PMID: 19459550<br \/>[14]. Sullivan JT, Grouper S, Walker MT, Parrish TB, McCarthy RJ, Wong CA. Lumbosacral cerebrospinal fluid volume in humans using three-dimensional magnetic resonance imaging. Anesth Analg 2006; 103:1306-1310. <br \/>https:\/\/doi.org\/10.1213\/01.ane.0000240886.55044.47<br \/>PMid:17056974<br \/>[15]. Hogan Q. Size of human lower thoracic and lumbosacral nerve roots. Anesthesiology 1996; 85:37-42. <br \/>https:\/\/doi.org\/10.1097\/00000542-199607000-00006<br \/>PMid:8694379<br \/>[16]. Moore KL, Dalley AF, Agur AMR (Eds.). Moore&#8217;s Clinically Oriented Anatomy, 7th Edition. Philadelphia: Lippincott Williams &amp; Wilkins; 2014.<br \/>[17]. Barolat G. Epidural spinal cord stimulation: anatomical and electrical properties of the intraspinal structures relevant to spinal cord stimulation and clinical correlations. Neuromodulation 1998;1:63-71. <br \/>https:\/\/doi.org\/10.1111\/j.1525-1403. 1998.tb00019.x<br \/>PMID: 22150938<br \/>[18]. Holsheimer J, Wesselink WA. Effect of anode-cathode configuration on paresthesia coverage in spinal cord stimulation. Neurosurgery 1997; 41:654-660. <br \/>https:\/\/doi.org\/10.1097\/00006123-199709000-00030<br \/>PMid:9310984<br \/>[19]. North RB, Ewend MG, Lawton MT, Piantadosi S. Spinal cord stimulation for chronic, intractable pain: superiority of &#8220;multi-channel&#8221; devices. Pain 1991; 44:119-130. <br \/>https:\/\/doi.org\/10.1016\/0304-3959(91)90125-H<br \/>PMid:2052378<\/p>\n<p style=\"text-align: justify;\">\n\t\t\t <div class=\"promo1\" style=\"background-color:#f7f7f7; border-color: #6b0e00 #e8e6e6 #e8e6e6;\">\n             \t <span style=\"color: #800000;\"><strong>Cite this article:<\/strong><\/span> Cheryl Melovitz-Vasan, Susan Huff, Nagaswami Vasan. Anatomical Considerations for Placing Spinal Cord Stimulators in Patients with Coronary Vascular Disease and Cardiomegaly. Int J Anat Res 2024;12(1):8855-8861. <strong>DOI:\u00a0<\/strong>10.16965\/ijar.2023.271\u00a0 \n             <\/div>\t\n\t\t\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Type of Article: \u00a0Original Research Volume 12; Issue 1 (March 2024) Page No.: 8855-8861 DOI:\u00a0https:\/\/dx.doi.org\/10.16965\/ijar.2023.271 Anatomical Considerations for Placing Spinal Cord Stimulators in Patients with Coronary Vascular Disease and Cardiomegaly Cheryl Melovitz-Vasan *1, Susan Huff 2, Nagaswami Vasan 3. 1 Associate Professor, Department of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, 08103.New Jersey,<br \/><a class=\"moretag\" href=\"https:\/\/www.ijmhr.org\/IntJAnatRes\/ijar-2023-271\">+ Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages\/2905"}],"collection":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/comments?post=2905"}],"version-history":[{"count":1,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages\/2905\/revisions"}],"predecessor-version":[{"id":2925,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages\/2905\/revisions\/2925"}],"wp:attachment":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/media?parent=2905"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}