{"id":2740,"date":"2022-12-04T11:22:27","date_gmt":"2022-12-04T11:22:27","guid":{"rendered":"https:\/\/www.ijmhr.org\/IntJAnatRes\/?page_id=2740"},"modified":"2022-12-04T11:22:27","modified_gmt":"2022-12-04T11:22:27","slug":"ijar-2022-252","status":"publish","type":"page","link":"https:\/\/www.ijmhr.org\/IntJAnatRes\/ijar-2022-252","title":{"rendered":"IJAR.2022.252"},"content":{"rendered":"
<\/i> DOWNLOAD PDF<\/span><\/a><\/div><\/div><\/div>
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Type of Article:<\/strong> \u00a0Original Research<\/h3>\n

Volume 10; Issue 4 (December 2022)<\/strong><\/h3>\n

Page No.:<\/strong> 8512-8522<\/h3>\n

DOI:\u00a0<\/strong>https:\/\/dx.doi.org\/10.16965\/ijar.2022.252<\/h3>\n

Effects of Vitamin D On Cisplatin Induced Heart and Lung Toxicity in Albino Rat<\/h3>\n

Sally Mahmoud Mohamed Hussein Omar 1<\/sup>, Marwa Mohamed Abd El Aziz Ahmed 2<\/sup>, Ola Abd El-Samie Mohamed Khalil *3<\/sup>, and Marwa Mahmoud Mady 4<\/sup>.<\/strong><\/p>\n

1<\/sup> Lecturer, Department of Anatomy and Embryology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.<\/p>\n

2<\/sup> Lecturer, Pathology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.<\/p>\n

*3<\/sup> Assistant Lecturer, Department of Anatomy and Embryology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.<\/p>\n

4<\/sup> Lecturer, Department of Anatomy and Embryology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.<\/p>\n

ORCiD:<\/strong><\/p>\n

Sally Mahmoud Mohamed Hussein Omar:<\/strong> 0000-0001-6601-4243<\/p>\n

Marwa Mohamed Abd El Aziz Ahmed: <\/strong>0000-0003-4230-7775<\/p>\n

Ola Abd El-Samie Mohamed Khalil: <\/strong>0000-0002-0728-5761<\/p>\n

Marwa Mahmoud Mady: <\/strong>0000-0003-2318-7368<\/p>\n

Corresponding author: <\/strong>Ola Abd El-Samie Mohamed Khalil, Assistant Lecturer, Department of Anatomy and Embryology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
E Mail: <\/strong>Ola.khalil@alexmed.edu.eg<\/p>\n

ABSTRACT<\/strong><\/p>\n

Background: <\/strong>\u00a0<\/strong>While Cisplatin (CP) is a powerful DNA alkylating agent used to treat many malignancies, its clinical use is linked to a number of negative side effects. It has been proposed that vitamin D can shield biological systems against harm caused by CP. The current study’s objective was to look into how vitamin D protects the rat heart and lung against cisplatin-induced damage.<\/p>\n

Material and methods<\/strong>: Thirty adult male Albino rats; 180\u2013220 g body weight were allocated into 3 groups; Group I (n=10) receiving saline, Group II (n=10); rats receiving CP (single dose of 6.5 mg\/kg intraperitoneal) and Group III (n=10); receiving CP and 50 ng\/kg\/day alfacalcidol.<\/p>\n

Results: <\/strong>Alterations included a significant increase in malondialdehyde (MDA) level in the CP group compared with the other groups (p value for comparing between control and each other group, statistically significant at p \u2264 0.05). Histopathologically, CP induced severe changes were observed. However, the CP-induced disturbances significantly improved by treatment with Vitamin D.\u00a0\u00a0\u00a0\u00a0<\/p>\n

Conclusion:<\/strong> According to this study, CP treatment significantly harmed rats’ hearts and lungs; however, treatment with vitamin D significantly lessened these harms.<\/p>\n

Keywords:<\/strong> Cisplatin, Immunohistochemical, Vitamin D, Malondialdehyde, Oxidative stress.<\/p>\n

REFERENCES<\/strong><\/p>\n

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\n\t\t\t

\n \t Cite this article:<\/strong><\/span> Sally Mahmoud Mohamed Hussein Omar, Marwa Mohamed Abd El Aziz Ahmed, Ola Abd El-Samie Mohamed Khalil, and Marwa Mahmoud Mady. Effects of Vitamin D On Cisplatin Induced Heart and Lung Toxicity in Albino Rat. Int J Anat Res 2022;10(4):8512-8522. DOI:\u00a0<\/strong>10.16965\/ijar.2022.252\u00a0 \n <\/div>\t\n\t\t\n\n\n

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Type of Article: \u00a0Original Research Volume 10; Issue 4 (December 2022) Page No.: 8512-8522 DOI:\u00a0https:\/\/dx.doi.org\/10.16965\/ijar.2022.252 Effects of Vitamin D On Cisplatin Induced Heart and Lung Toxicity in Albino Rat Sally Mahmoud Mohamed Hussein Omar 1, Marwa Mohamed Abd El Aziz Ahmed 2, Ola Abd El-Samie Mohamed Khalil *3, and Marwa Mahmoud Mady 4. 1 Lecturer,
+ Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages\/2740"}],"collection":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/comments?post=2740"}],"version-history":[{"count":1,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages\/2740\/revisions"}],"predecessor-version":[{"id":2751,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages\/2740\/revisions\/2751"}],"wp:attachment":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/media?parent=2740"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}