{"id":2208,"date":"2020-03-05T14:13:08","date_gmt":"2020-03-05T14:13:08","guid":{"rendered":"http:\/\/www.ijmhr.org\/IntJAnatRes\/?page_id=2208"},"modified":"2020-03-05T14:13:08","modified_gmt":"2020-03-05T14:13:08","slug":"ijar-2020-108","status":"publish","type":"page","link":"https:\/\/www.ijmhr.org\/IntJAnatRes\/ijar-2020-108","title":{"rendered":"IJAR.2020.108"},"content":{"rendered":"
<\/i> DOWNLOAD PDF<\/span><\/a><\/div><\/div><\/div>
<\/i> Table of Contents<\/span><\/a><\/div><\/div><\/div><\/div>\n

Type of Article:<\/strong>\u00a0\u00a0Original Research<\/h3>\n

Volume 8; Issue 1.3 (March 2020)<\/strong><\/h3>\n

Page No.:<\/strong>\u00a07383-7385<\/h3>\n

DOI:\u00a0<\/strong>https:\/\/dx.doi.org\/10.16965\/ijar.2020.108<\/h3>\n

VALPROATE INDUCED NEPHROTOXICITY ON FETAL MICE KIDNEY<\/h3>\n

Pratibha Shakya 1<\/sup>, Neelesh Kumar Shakya *2<\/sup>, C. Mohanty 3<\/sup>.<\/strong><\/p>\n

1<\/sup> Assistant Professor, Anatomy Department, Integral Institute of Medical Sciences & Research, Integral University, Dasauli, Lucknow (U.P.), India.<\/p>\n

*2<\/sup> Forensic Medicine & Toxicology, Assistant Professor, Department of Forensic Medicine & Toxicology, Integral Institute of Medical Sciences & Research, Integral University, Dasauli, Lucknow (U.P.), India.<\/p>\n

3<\/sup> Professor & Head, Anatomy Department, Institute of Medical Sciences, Banaras Hindu University, Varanasi (U.P.), India.<\/p>\n

Corresponding Author:<\/strong> Dr. Neelesh Kumar Shakya, M.D. Forensic Medicine & Toxicology, Assistant Professor, Department of Forensic Medicine & Toxicology, Integral Institute of Medical Sciences & Research, Integral University, Dasauli, Lucknow (U.P.), India. E-Mail<\/strong>: neelesh.shakya12@gmail.com<\/p>\n

ABSTRACT<\/h3>\n

Background:<\/strong> Valproate is an antiepileptic drug which is also known as 2-propylvaleric acid. Valproic acid is presently the most widely used antiepileptic drug because of its antiepileptic effectiveness in a broad range of seizure types: tonic-clonic, myoclonic, absence and partial seizures. Present work was done to evaluate the gross and histological effect of valproate on fetal mice kidney.<\/p>\n

Materials and Methods: <\/strong>This study was done in anatomy department of Institute of medical sciences, Banaras Hindu University, Varanasi (U.P.). Single dose of valproate (200mg\/kg) was administered intraperitoneally on 8th<\/sup> day of gestation and then fetuses were collected at the 18th<\/sup> day of gestation.<\/p>\n

Results:<\/strong> Kidney was reduced in size in valproate treated group fetuses as compared to kidney of control group fetuses. On histological examination, distorted developing nephrons \u00a0and clumping of bowman capsule in developed nephrons were seen.<\/p>\n

Conclusions:<\/strong> Various authors worked on valproate treated adult mice kidney. There are only few study conducted on kidney of mice fetus.\u00a0 In present study, valproate was found teratogenic at the dose of 200mg\/kg so it should be avoided in human pregnancy if possible.<\/p>\n

KEY WORDS: <\/strong>Valproate, Fetal mice, Kidney, Teratogenic.<\/p>\n

REFERENCES<\/strong><\/p>\n

    \n
  1. Hale F. Pigs born with eyebolls. J Hered 1933;24:105\u2013106.<\/li>\n
  2. Warkany J, Nelson RC. Appearance of skeletal abnormalities in the offspring of rats on a deficient diet.Science\u00a01940;92:383\u2013384.<\/li>\n
  3. Gottlicher M. Valproic acid: an old drug newly discovered as inhibitor of histone deacetylases. Annals of Hematology 2004;83:91\u201392.<\/li>\n
  4. Vorhees CV<\/a>. Teratogenicity and developmental toxicity of valproic acid in rats. Teratology 1987;5:195-202.<\/li>\n
  5. Sonoda T, Ohdo S, Ohba K, Okishima T, Hayakawa K. Teratogenic effects of sodium valproate\u00a0in the Jcl: ICR mouse fetus. Acta Paediatr Jpn1990;32:502-507.<\/li>\n
  6. Elmazar MMA, Thiel R,Nau Effect of supplementation with folinic acid, vitamin B6<\/sub>, and vitamin B12 <\/sub>on valproic acid-induced teratogenesis in mice. Fundamental and Applied Toxicology 1992;18:389\u2013394.<\/li>\n
  7. Kozma C. Valproic acid embryopathy: report of two siblings with further expansion of the phenotypic abnormalities and a review of the literature. Am J Med Genet 2001;98:168-175.<\/li>\n
  8. Malm H and Kajantie E. Valproate embryopathy in three sets of siblings: further proof of hereditary susceptibility. Neurology 2002;59:630-633.<\/li>\n
  9. Aktas A, Nergiz Y, Akkus M, Nasir Y. The effects of valproic acid on renal corpuscle of pregnant rats and protective role of folic acid andvitamin E. African journal of biotechnology 2010;9(34):5605-5610.\u00a0 \u00a0\u00a0<\/strong><\/li>\n<\/ol>\n

    \n\t\t\t

    \n \t Cite this article:<\/strong><\/span> Pratibha Shakya, Neelesh Kumar Shakya, C. Mohanty. VALPROATE INDUCED NEPHROTOXICITY ON FETAL MICE KIDNEY. Int J Anat Res 2020;8(1.3):7383-7385.\u00a0DOI:\u00a0<\/strong>10.16965\/ijar.2020.108\u00a0 \n <\/div>\t\n\t\t\n","protected":false},"excerpt":{"rendered":"

    Type of Article:\u00a0\u00a0Original Research Volume 8; Issue 1.3 (March 2020) Page No.:\u00a07383-7385 DOI:\u00a0https:\/\/dx.doi.org\/10.16965\/ijar.2020.108 VALPROATE INDUCED NEPHROTOXICITY ON FETAL MICE KIDNEY Pratibha Shakya 1, Neelesh Kumar Shakya *2, C. Mohanty 3. 1 Assistant Professor, Anatomy Department, Integral Institute of Medical Sciences & Research, Integral University, Dasauli, Lucknow (U.P.), India. *2 Forensic Medicine & Toxicology, Assistant Professor,
    + Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages\/2208"}],"collection":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/comments?post=2208"}],"version-history":[{"count":1,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages\/2208\/revisions"}],"predecessor-version":[{"id":2219,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages\/2208\/revisions\/2219"}],"wp:attachment":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/media?parent=2208"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}