{"id":2045,"date":"2019-09-05T16:06:17","date_gmt":"2019-09-05T16:06:17","guid":{"rendered":"http:\/\/www.ijmhr.org\/IntJAnatRes\/?page_id=2045"},"modified":"2019-09-05T16:06:17","modified_gmt":"2019-09-05T16:06:17","slug":"ijar-2019-273","status":"publish","type":"page","link":"https:\/\/www.ijmhr.org\/IntJAnatRes\/ijar-2019-273","title":{"rendered":"IJAR.2019.273"},"content":{"rendered":"<div class=\"su-row\"><div class=\"su-column su-column-size-1-2\"><div class=\"su-column-inner su-u-clearfix su-u-trim\"><div class=\"su-button-center\"><a href=\"https:\/\/www.ijmhr.org\/ijar.7.3\/IJAR.2019.273.pdf\" class=\"su-button su-button-style-default\" style=\"color:#FFFFFF;background-color:#6b0e00;border-color:#560c00;border-radius:5px;-moz-border-radius:5px;-webkit-border-radius:5px\" target=\"_self\"><span style=\"color:#FFFFFF;padding:6px 16px;font-size:13px;line-height:20px;border-color:#98574d;border-radius:5px;-moz-border-radius:5px;-webkit-border-radius:5px;text-shadow:none;-moz-text-shadow:none;-webkit-text-shadow:none\"><i class=\"sui sui-cloud-download\" style=\"font-size:13px;color:#FFFFFF\"><\/i> DOWNLOAD PDF<\/span><\/a><\/div><\/div><\/div> <div class=\"su-column su-column-size-1-2\"><div class=\"su-column-inner su-u-clearfix su-u-trim\"><div class=\"su-button-center\"><a href=\"https:\/\/ijmhr.org\/ijar-vol-7-3.htm\" class=\"su-button su-button-style-default\" style=\"color:#FFFFFF;background-color:#6b0e00;border-color:#560c00;border-radius:5px;-moz-border-radius:5px;-webkit-border-radius:5px\" target=\"_self\"><span style=\"color:#FFFFFF;padding:6px 16px;font-size:13px;line-height:20px;border-color:#98574d;border-radius:5px;-moz-border-radius:5px;-webkit-border-radius:5px;text-shadow:none;-moz-text-shadow:none;-webkit-text-shadow:none\"><i class=\"sui sui-book\" style=\"font-size:13px;color:#FFFFFF\"><\/i> Table of Contents<\/span><\/a><\/div><\/div><\/div><\/div>\n<h3 style=\"text-align: justify;\"><strong>Type of Article:<\/strong>\u00a0\u00a0Original Research<\/h3>\n<h3 style=\"text-align: justify;\"><strong>Volume 7; Issue 3.3 (September 2019)<\/strong><\/h3>\n<h3 style=\"text-align: justify;\"><strong>Page No.:<\/strong>\u00a06970-6975<\/h3>\n<h3 style=\"text-align: justify;\"><strong>DOI:\u00a0<\/strong>https:\/\/dx.doi.org\/10.16965\/ijar.2019.273<\/h3>\n<h3 style=\"text-align: justify;\">MORPHOLOGICAL CHANGES IN HUMAN FETAL SPLEEN AT DIFFERENT GESTATIONAL AGES<\/h3>\n<p style=\"text-align: justify;\"><strong>Thomas S *<sup>1<\/sup>, Sinha DN <sup>2<\/sup>, Singh AK <sup>3<\/sup>, Deopa D <sup>4<\/sup>, Niranjan R <sup>5<\/sup>.<\/strong><\/p>\n<p><sup>*1<\/sup> Assistant Professor, Department of Anatomy, Sri Ram Murti Smarak Institute of Medical sciences (SRMS IMS), Bhojipura, District- Bareilly, Uttar Pradesh-India.<\/p>\n<p style=\"text-align: justify;\"><sup>2- 5<\/sup> Department of Anatomy, GMC Haldwani, Uttarakhand, India.<\/p>\n<p style=\"text-align: justify;\"><strong>Address for Correspondence: <\/strong>Dr Sonali Thomas, Assistant Professor, Department of Anatomy, Sri Ram Murti Smarak Institute of Medical sciences (SRMS IMS), Bhojipura, District- Bareilly (Uttar Pradesh-India). Pin code- 243002. <strong>E-Mail:<\/strong> sonathomas0017@gmail.com.<\/p>\n<p style=\"text-align: justify;\"><strong>ABSTRACT:<\/strong><\/p>\n<p style=\"text-align: justify;\"><strong>Background: <\/strong>The purpose of the study was desired to investigate and observe the variations in the morphology of spleen in human fetuses. The spleen is the largest secondary lymphoid organ, in the fetal stage it also performs the role of haematopoiesis. It acts as a blood filter, and also acts as storage site for iron, erythrocytes, and platelets<em>.<\/em><\/p>\n<p style=\"text-align: justify;\"><strong>Materials and Methods: <\/strong>This study has been carried out on spleen of 40 formalin preserved human fetuses (19 males and 21 females) of different gestational ages, in the Department of Anatomy, Government Medical College, Haldwani over a period of two years (i.e. 2014- 2016), with due regards on ethical grounds. Various gross parameters of spleen such as its location, shape, relations, notches &amp; fissures and ligaments were observed and the results were statistically analyzed.<\/p>\n<p style=\"text-align: justify;\"><strong>Results:<\/strong> Spleens in all the fetuses was located in the left hypochondrium. 60% of the fetal spleens were wedge shaped. While stomach was related to the spleen in all the gestational ages, kidney and left colic flexure were not related to the spleen in the early age of the fetus. Liver and left adrenal gland also showed relations with the fetal spleen. Maximum number of notches was present in the superior border followed by inferior border and lateral pole. Fissures were also seen in 11 spleens.<\/p>\n<p style=\"text-align: justify;\"><strong>Conclusion:<\/strong> Knowledge about prenatal ontogenesis of the spleen will help to understand the mechanisms of pathology in the organ and create methods of diagnosis and prevention.<\/p>\n<p style=\"text-align: justify;\"><strong>KEY WORDS:<\/strong> Spleen, Morphology, Fetus, Wedge, Notches, Fissures.<\/p>\n<p style=\"text-align: justify;\"><strong>REFERENCES<\/strong><\/p>\n<ol>\n<li style=\"text-align: justify;\">Standring S. Spleen. Gray\u2019s Anatomy. The Anatomical Basis of the Clinical Practice. 40th edition. Edinburgh: Elsevier Churchill Livingstone; 2008: 1239-44.<\/li>\n<li style=\"text-align: justify;\">Moore KL, Persaud TVN, Torchia MG. The digestive system. The developing human: Clinically oriented embryology: 8<sup>th<\/sup> New York, New Delhi: Elsevier publication; 2008: 224.<\/li>\n<li style=\"text-align: justify;\">Sadler TW. Langman\u2019s Medical Embryology. 12<sup>th<\/sup> Philadelphia: Wolters Kluwer, Lippincott Williams &amp; Wilkins; 2012: 213.<\/li>\n<li style=\"text-align: justify;\">Practical embalming. Textbook of \u2018Embalming principles and legal aspects\u2019.1<sup>st<\/sup> edition. New Delhi: Jaypee publishers; 1996: pp 131-135.<\/li>\n<li style=\"text-align: justify;\">Romanes GJ. The abdominal cavity. In: Cunningham manual of practical anatomy. 15<sup>th<\/sup> New York: Oxford university press; 2008;126-127.<\/li>\n<li style=\"text-align: justify;\">\u00dcng\u00f6r B, Malas MA, Sulak O, Albay S. Development of spleen during the fetal period. Surg Radiol Anat 2007;29:543\u2013550.<\/li>\n<li style=\"text-align: justify;\">Saheb H, Velichety SD, Haseena S. Morphological and Morphometric study of Human Foetal Spleen. Int J Anat Res. 2014; 2(1):234-38.<\/li>\n<li style=\"text-align: justify;\">Mukhia R, Mukherjee A, Sabnis A. Histogenesis of Human Fetal Spleen. Int J Anat Res 2016; 4 (1):2119-2124.<\/li>\n<li style=\"text-align: justify;\">Radhika D, Vijayanirmala B. Morphometry of spleen. J. Evid. Based Med. Healthc. 2016; 3(28):1297-1300.<\/li>\n<li style=\"text-align: justify;\">Singh R, Kumari G. Morphological Assessment of Human Foetal Spleen. Asian Journal of Biomedical and Pharmaceutical Sciences,2016;6(52):19-21.<\/li>\n<li style=\"text-align: justify;\">Sudharani K, Usha M, Ratnachary P. A Study of Regional Anatomy of Spleen. Journal of Evidence based Medicine and Healthcare. April 13, 2015; 2 (15): 2125-2133.<\/li>\n<li style=\"text-align: justify;\">Chaudhari ML, Maheria PB, Lakhani C, Menezes VR. Morphological Variations of Human Spleen and its Clinical Significance. Int J Med Res Rev.2014; 2(1):16-20.<\/li>\n<li style=\"text-align: justify;\">Chaware PN, Belsare SM, Kulkarni YR, Pandit SV, Ughade JM. The Morphological Variations of the Human Spleen Journal of Clinical and Diagnostic Research. April 2012; 6(2): 159-162.<\/li>\n<li style=\"text-align: justify;\">Das S, Latiff AA, Suhaimi FH, Ghazali H, Othman F. Anomalous splenic notches: a cadaveric study with clinical importance. Bratisk Lek Listy. 2008; 109 (11): 513- 516.<\/li>\n<li style=\"text-align: justify;\">Setty SNRS, Katikireddi RS. A cadaveric study of human splenic notches and fissures. Int J Health Sci Res. 2013; 3(9):40-44.<\/li>\n<li style=\"text-align: justify;\">Moore KL, Dalley AF, Agur AMR. Spleen in Abdomen. Clinically oriented anatomy. 6<sup>th<\/sup> New Delhi: Wolters Kluwers (India) pvt ltd 2010;263-265.<\/li>\n<\/ol>\n<p style=\"text-align: justify;\">\n\t\t\t <div class=\"promo1\" style=\"background-color:#f7f7f7; border-color: #6b0e00 #e8e6e6 #e8e6e6;\">\n             \t <span style=\"color: #800000;\"><strong>Cite this article:<\/strong><\/span> Thomas S, Sinha DN, Singh AK, Deopa D, Niranjan R. MORPHOLOGICAL CHANGES IN HUMAN FETAL SPLEEN AT DIFFERENT GESTATIONAL AGES. Int J Anat Res 2019;7(3.3):6970-6975.\u00a0<strong>DOI:\u00a0<\/strong>10.16965\/ijar.2019.273\u00a0 \n             <\/div>\t\n\t\t\n","protected":false},"excerpt":{"rendered":"<p>Type of Article:\u00a0\u00a0Original Research Volume 7; Issue 3.3 (September 2019) Page No.:\u00a06970-6975 DOI:\u00a0https:\/\/dx.doi.org\/10.16965\/ijar.2019.273 MORPHOLOGICAL CHANGES IN HUMAN FETAL SPLEEN AT DIFFERENT GESTATIONAL AGES Thomas S *1, Sinha DN 2, Singh AK 3, Deopa D 4, Niranjan R 5. *1 Assistant Professor, Department of Anatomy, Sri Ram Murti Smarak Institute of Medical sciences (SRMS IMS), Bhojipura,<br \/><a class=\"moretag\" href=\"https:\/\/www.ijmhr.org\/IntJAnatRes\/ijar-2019-273\">+ Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages\/2045"}],"collection":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/comments?post=2045"}],"version-history":[{"count":1,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages\/2045\/revisions"}],"predecessor-version":[{"id":2050,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages\/2045\/revisions\/2050"}],"wp:attachment":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/media?parent=2045"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}