{"id":2007,"date":"2019-08-12T16:06:06","date_gmt":"2019-08-12T16:06:06","guid":{"rendered":"http:\/\/www.ijmhr.org\/IntJAnatRes\/?page_id=2007"},"modified":"2019-08-12T16:06:06","modified_gmt":"2019-08-12T16:06:06","slug":"ijar-2019-247","status":"publish","type":"page","link":"https:\/\/www.ijmhr.org\/IntJAnatRes\/ijar-2019-247","title":{"rendered":"IJAR.2019.247"},"content":{"rendered":"<div class=\"su-row\"><div class=\"su-column su-column-size-1-2\"><div class=\"su-column-inner su-u-clearfix su-u-trim\"><div class=\"su-button-center\"><a href=\"https:\/\/www.ijmhr.org\/ijar.7.3\/IJAR.2019.247.pdf\" class=\"su-button su-button-style-default\" style=\"color:#FFFFFF;background-color:#6b0e00;border-color:#560c00;border-radius:5px;-moz-border-radius:5px;-webkit-border-radius:5px\" target=\"_self\"><span style=\"color:#FFFFFF;padding:6px 16px;font-size:13px;line-height:20px;border-color:#98574d;border-radius:5px;-moz-border-radius:5px;-webkit-border-radius:5px;text-shadow:none;-moz-text-shadow:none;-webkit-text-shadow:none\"><i class=\"sui sui-cloud-download\" style=\"font-size:13px;color:#FFFFFF\"><\/i> DOWNLOAD PDF<\/span><\/a><\/div><\/div><\/div> <div class=\"su-column su-column-size-1-2\"><div class=\"su-column-inner su-u-clearfix su-u-trim\"><div class=\"su-button-center\"><a href=\"https:\/\/ijmhr.org\/ijar-vol-7-3.htm\" class=\"su-button su-button-style-default\" style=\"color:#FFFFFF;background-color:#6b0e00;border-color:#560c00;border-radius:5px;-moz-border-radius:5px;-webkit-border-radius:5px\" target=\"_self\"><span style=\"color:#FFFFFF;padding:6px 16px;font-size:13px;line-height:20px;border-color:#98574d;border-radius:5px;-moz-border-radius:5px;-webkit-border-radius:5px;text-shadow:none;-moz-text-shadow:none;-webkit-text-shadow:none\"><i class=\"sui sui-book\" style=\"font-size:13px;color:#FFFFFF\"><\/i> Table of Contents<\/span><\/a><\/div><\/div><\/div><\/div>\n<h3 style=\"text-align: justify;\"><strong>Type of Article:<\/strong>\u00a0\u00a0Original Research<\/h3>\n<h3 style=\"text-align: justify;\"><strong>Volume 7; Issue 3.2 (August 2019)<\/strong><\/h3>\n<h3 style=\"text-align: justify;\"><strong>Page No.:<\/strong>\u00a06871-6876<\/h3>\n<h3 style=\"text-align: justify;\"><strong>DOI:\u00a0<\/strong>https:\/\/dx.doi.org\/10.16965\/ijar.2019.247<\/h3>\n<h3 style=\"text-align: justify;\">RADIOLOGICAL AND GENETIC EXPRESSION OF NEURAL TUBE DEFECTS<\/h3>\n<p style=\"text-align: justify;\"><strong>Gayatri. N *<sup>1<\/sup>, K.K.Chaitanya <sup>2<\/sup>.<\/strong><\/p>\n<p style=\"text-align: justify;\">*<sup>1<\/sup> Associate Professor of Anatomy, MNR Medical College and Hospital, Sangareddy, Telangana, India.<\/p>\n<p style=\"text-align: justify;\"><sup>2<\/sup> Assistant Professor of Anatomy, MNR Medical College and Hospital, Sangareddy, Telangana, India.<\/p>\n<p style=\"text-align: justify;\"><strong>Address for Correspondence: <\/strong>Dr.Gayatri. N, Associate Professor of Anatomy, MNR Medical College and Hospital, Sangareddy-502294, Telangana, India. Mobile no.: +919866084854.\u00a0<strong>E-Mail:<\/strong> drgayatri1884@gmail.com<\/p>\n<p style=\"text-align: justify;\"><strong>ABSTRACT:<\/strong><\/p>\n<p style=\"text-align: justify;\"><strong>Background: <\/strong>Neural tube defects (NTDs) are the most common birth defects which mainly affect developing foetuses, with a high incidence rate in India and main causes of it been nutritional deficiencies and genetic predisposition. Folic acid supplementation brought decline in the incidence of NTDs.<\/p>\n<p style=\"text-align: justify;\"><strong>Materials:<\/strong> This study was conducted on 1000 dead foetuses in Anatomy department, over a period of two years from 2017- 2019 .The dead foetuses were brought from the gynaecology and obstetrics department. A proper family history and obstetrics history was collected. The foetuses were embalmed and later studied for NTDs in detail.<\/p>\n<p style=\"text-align: justify;\"><strong>Conclusion: <\/strong>Comparing the results with the previous studies it is clearly evident that the incidence of NTDs have significantly reduced from 11.42\/1000 births to 0.2 to 10\/1000 births. In most of the previous studies NTDs had a female preponderance whereas in present study there is equal preponderance. In older studies, Spina bifida was the most common NTDs followed by anencephaly. But in the present study it is the same. Incidence of NTDs has reduced due to various reasons like prenatal screening tests forfoetal anomalies and folic acid supplementation.<\/p>\n<p style=\"text-align: justify;\"><strong>KEY WORDS: <\/strong>neural tube defects, spina bifida, neuralation, ultrasonography, karyotype.<\/p>\n<p style=\"text-align: justify;\"><strong>REFERENCES<\/strong><\/p>\n<ol>\n<li style=\"text-align: justify;\">Copp, A.J; Greene,N.D.Neural tube defects- Disorder of neuralation and related embryonic processes. Wiley Interdisciplinary. Rev.Dev.Bio.2013,2,213-227<\/li>\n<li style=\"text-align: justify;\">Richard G E. Neural tube defects in the neonatal period. http:\/\/emedicine.medscape.com\/article\/1825866<u>.<\/u><\/li>\n<li style=\"text-align: justify;\">Frosch MP, Anthony DC,Girolami UD: The Central Nervous System. In: Robbins and Cotran, Pathological basis of disease.Eds.V Kumar K Abbas, N Fausto.7<sup>th<\/sup> Edition: W.B.Saunders Elsevier, Philadelphia. 2004; pp1353-1354.<\/li>\n<li style=\"text-align: justify;\">Johnson KM,SuarezL,Felkner MM, Hendricks K:Prevalence of Craniorachischisis in a Texas-Mexico border population .Birth defects Research ,Part A:Clinical and Molecular Teratology ,2004;70(2):92-94. ZohnIE,AndersonKV,Niswander L. The Hectd1 ubiquitin ligase is required for development of the head mesenchyme and neural tube closure .Dev Biol.2007:;306:208-221.[PubMed :17442300]<\/li>\n<li style=\"text-align: justify;\">Mustafa A.S, Waleed R M, M Z. Seidahmed ,Classification,clinical features , and genetics of neural tube defects. Saudi Med J 2014; 35: S5-S14.<\/li>\n<li style=\"text-align: justify;\">Menasinkai: A Study of neural tube defects.Journal. Anatomical society of India.Vol.4 (1), 2011; 59(2) 162-167(2010).<\/li>\n<li style=\"text-align: justify;\">Deopujari R, Mangalgiri A, Dixit A and Longia G S. Neural tube defect Spectrum \u2013 Study of Craniorachischisis.People\u2019s Journal of Society of Research 2011;4(1):23-7.<\/li>\n<li style=\"text-align: justify;\">Cunningham F G , Leveno KJ, Bloom SL,Hauth JC ,Gilstrap L, WenstromKD:Genetics .In: Willam\u2019s Obstetrics.22<sup>nd<\/sup> Edition ;Mc Graw- Hill, New York, 2005;pp 285-312<\/li>\n<li style=\"text-align: justify;\">Wu JI,RajendraR,Barsi JC, DurfeeL,BenitoE,GaoG,et al. Targeted disruption of Mib2 causes exencephaly with a variable penetrance . Genesis. 2007; 45:722-727. [PubMed: 17987667].<\/li>\n<li style=\"text-align: justify;\">NarimatsuM,BoseR,PyeM,ZhangL, Miller B,ChingP,etal .Regulation of planar cell polarity by Smurf Ubiquitin ligase. Cell.2009; 137:295-307. [PubMed: 19379695].<\/li>\n<li style=\"text-align: justify;\">Myla EM,Benjamin B, Shawn F,Gideon K. Maternal Hyperthermia and the risk of Neural Tube Defects In Offspring .Lippincott Williams &amp; Wilkins 2005, Volume 16(2):216-19.<strong>\u00a0<\/strong><\/li>\n<\/ol>\n<p style=\"text-align: justify;\">\n\t\t\t <div class=\"promo1\" style=\"background-color:#f7f7f7; border-color: #6b0e00 #e8e6e6 #e8e6e6;\">\n             \t <span style=\"color: #800000;\"><strong>Cite this article:<\/strong><\/span> Gayatri. N, K.K.Chaitanya. RADIOLOGICAL AND GENETIC EXPRESSION OF NEURAL TUBE DEFECTS. Int J Anat Res 2019;7(3.2):6871-6876.\u00a0<strong>DOI:\u00a0<\/strong>10.16965\/ijar.2019.247\u00a0 \n             <\/div>\t\n\t\t\n","protected":false},"excerpt":{"rendered":"<p>Type of Article:\u00a0\u00a0Original Research Volume 7; Issue 3.2 (August 2019) Page No.:\u00a06871-6876 DOI:\u00a0https:\/\/dx.doi.org\/10.16965\/ijar.2019.247 RADIOLOGICAL AND GENETIC EXPRESSION OF NEURAL TUBE DEFECTS Gayatri. N *1, K.K.Chaitanya 2. *1 Associate Professor of Anatomy, MNR Medical College and Hospital, Sangareddy, Telangana, India. 2 Assistant Professor of Anatomy, MNR Medical College and Hospital, Sangareddy, Telangana, India. Address for Correspondence:<br \/><a class=\"moretag\" href=\"https:\/\/www.ijmhr.org\/IntJAnatRes\/ijar-2019-247\">+ Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages\/2007"}],"collection":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/comments?post=2007"}],"version-history":[{"count":1,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages\/2007\/revisions"}],"predecessor-version":[{"id":2018,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages\/2007\/revisions\/2018"}],"wp:attachment":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/media?parent=2007"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}