{"id":1819,"date":"2019-04-06T03:04:12","date_gmt":"2019-04-06T03:04:12","guid":{"rendered":"http:\/\/www.ijmhr.org\/IntJAnatRes\/?page_id=1819"},"modified":"2019-04-06T03:04:12","modified_gmt":"2019-04-06T03:04:12","slug":"ijar-2019-148","status":"publish","type":"page","link":"https:\/\/www.ijmhr.org\/IntJAnatRes\/ijar-2019-148","title":{"rendered":"IJAR.2019.148"},"content":{"rendered":"
<\/i> DOWNLOAD PDF<\/span><\/a><\/div><\/div><\/div>
<\/i> Table of Contents<\/span><\/a><\/div><\/div><\/div><\/div>\n

Type of Article:<\/strong>\u00a0\u00a0Case Report<\/h3>\n

Volume 7; Issue 2.1 (April 2019)<\/strong><\/h3>\n

Page No.:<\/strong>\u00a06479-6483<\/h3>\n

DOI:\u00a0<\/strong>https:\/\/dx.doi.org\/10.16965\/ijar.2019.148<\/h3>\n

CLUSTERED ORIGIN OF LEFT CORONARY ARTERY FROM THE LEFT SINUS OF VALSALVA: UNCHARACTERISTIC DEVELOPMENTAL EVENT IN THE TEMPORALLY REGULATED PROCESS<\/h3>\n

Cheryl Melovitz-Vasan 1<\/sup>, Lauren Printz 2<\/sup>, Nagaswami Vasan 3<\/sup>.<\/strong><\/p>\n

1 <\/sup>Associate Professor, Department of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, New Jersey 08103, USA.<\/p>\n

2 <\/sup>Anatomy Laboratory Technical Staff, Department of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, New Jersey 08103, USA.<\/p>\n

*3 <\/sup>Professor of Anatomy, Department of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, New Jersey 08103, USA.<\/p>\n

Corresponding author: <\/strong>Nagaswami Vasan, D.V.M., M.V.Sc., Ph.D, Professor of Anatomy, Department of Biomedical Sciences, Cooper Medical School of Rowan University, 401 South Broadway, Camden, New Jersey 08103, USA. Phone: +1 (856) 361-2890\u00a0E-Mail:<\/strong> vasan@rowan.edu<\/p>\n

ABSTRACT:<\/strong><\/p>\n

Background: <\/strong>The coronary artery development is a sequential and progressively regulated process. However, there are number of reports available on the disturbance to this temporal process resulting in variations of the artery. In these instances, the function of the coronary arteries was normal in providing blood supply to the heart. The normal and abnormal coronary artery development has been studied using variety of approaches and the knowledge continues to evolve.<\/p>\n

Materials and Methods: <\/strong>The cadaveric specimen was obtained from the \u201cwilled body program\u201d for the purpose of student dissection. We report here an anomaly found in a 94-year old Caucasian male died of cerebral artery infarction.<\/p>\n

Results and Observations: <\/strong>We observed that the left coronary artery arose from the coronary ostium in a cluster of multiple branches. The right coronary artery arose normally from the right coronary ostium. Further dissection showed the co-dominant nature of the left and right coronary arteries in providing blood supply to the posterior aspect of the heart and the interventricular septum.<\/p>\n

Conclusions: <\/strong>Knowledge of coronary artery and its disposition is important in clinical practice especially in coronary artery stent placement, coronary artery bypass surgery and coronary sinus catheterization.<\/p>\n

KEY WORDS: <\/strong>Coronary artery, clustered left coronary artery, normal coronary development, anomalous developmental process, clinical significance.<\/p>\n

REFERENCES<\/strong><\/p>\n

    \n
  1. Reese DE, Mikawa T, Bader DM. Development of the coronary vessel system.\u00a0Circ Res. 2002; 91: 761\u2013768.<\/li>\n
  2. Viragh S, Challice CE. The origin of the epicardium and the embryonic myocardial circulation in the mouse. Anat Rec. 1981; 201: 157\u2013168.<\/li>\n
  3. Anderson RH, Chiu IS, Spicer DE, Hlavacek AM. Understanding coronary arterial anatomy in the congenitally malformed heart. Cardiology in the Young. 2012; 22: 647\u2013654.<\/li>\n
  4. Perez-Pomares JM, Phelps A, Sedmedmerova M, Carmona R, Gonzalez-Iriarte M, Munoz-Chapuli R, Wessels A. Experimental studies on the spatiotemporal expression of WT1 and RALDH2 in the embryonic avian heart: a model for the regulation of myocardial and valvuloseptal development by epicardially derived cells (EPDCs). Dev Biol. 2002; 247: 307\u2013326.<\/li>\n
  5. Perez-Pomares JM, De La Pompa JL. Signaling during epicardium and coronary vessel development. Circ Res. 2011; 109: 1429-1442.<\/li>\n
  6. Bogers AJ, Gittenberger-de Groot AC, Poelmann RE, Peault BM, Huysmans HA. Development of the origin of the coronary arteries, a matter of ingrowth or outgrowth? Anat Embryol. 1989; 180: 437\u2013441.<\/li>\n
  7. Angelini P. Normal and anomalous coronary arteries: definitions and classification. Am Heart J. 1989; 117: 418\u2013434.<\/li>\n
  8. Silva-Junior GO, Miranda SWS, Mandrim-De-Lacerda CA. Origin and development of the coronary arteries. Int. J. Morphol. 2009; 27: 891-898.<\/li>\n
  9. Erne P. Congenital Anomalies of the Coronary Arteries. European Cardiology. 2009; 5: 12-14.<\/li>\n
  10. Nowak D, Kozlowska H, Zurada A. The relationship between the dimensions of the right coronary artery and the type of coronary vasculature in human Folia morphologica. 2011; 70: 13-17.<\/li>\n
  11. Fuster V, Alexander RW, O’rourke RA. Hurst’s The Heart<\/em>(10th ed.). McGraw-Hill, 2001; p.\u00a053.<\/li>\n
  12. Theveniau-Heveniau-Ruissy M, Dandonneau M, Mesbah K, Ghez O, Mattei MG, Miquerol L, Kelly RG. The de122q11.2 candidate gene Tbx1 controls regional outflow tract identity and coronary artery patterning. Circ Res. 2008; 103: 142\u2013148.<\/li>\n
  13. Chiu IS, Anderson RH. Can We Better Understand the Known Variations in Coronary Arterial Anatomy? Ann Thoracic Surg. 2012; 94: 1751-1760.<\/li>\n
  14. Mahowald JM,\u00a0Blieden LC,\u00a0Coe JI,\u00a0Edwards JE. Ectopic origin of a coronary artery from the aorta. Sudden death in 3 of 23 patients. 1986;\u00a089: 668-72.<\/li>\n
  15. Singh S, Ajayi N, Lazarus L, Satyapal KS. Morphologic Relationship between the Coronary Arteries during Fetal Development. Int J Morphol. 2017; 35: 1197-1202.<\/li>\n
  16. Ogene\u2019O JA, Misiani MK, Olabu BO, Waisiko BM, Murunga A. Variant termination of the left coronary artery: pentafurcation is not uncommon. Eur. J. Anat. 2014; 18: 98-101.<\/li>\n
  17. Viragh S,\u00a0Gittenberger-De Groot AC,\u00a0Poelmann RE,\u00a0Kalman F. Early development of quail heart epicardium and associated vascular and glandular structures. Anat Embryol (Berl).\u00a01993; 188: 381-393.<\/li>\n
  18. Ando K, Nakajima Y, Yamagishi T, Yamamoto S, Nakamura Development of proximal coronary arteries in quail embryonic heart: multiple capillaries penetrating the aortic sinus fuse to form main\u00a0coronary trunk. Circ. Res. 2004; 94: 346-352.<\/li>\n
  19. Tomanek RJ. Developmental Progression of the Coronary Vasculature in Human Embryos and Fetuses. The Anatomical Record. 2016; 299:25-41.<\/li>\n
  20. Loukas M, Groat C, Khangura R, Owens DG. The normal and abnormal anatomy of the coronary arteries. Clinical Anatomy. 2009; 22:114-128.<\/li>\n<\/ol>\n

    \n\t\t\t

    \n \t Cite this article:<\/strong><\/span> Cheryl Melovitz-Vasan, Lauren Printz, Nagaswami Vasan. CLUSTERED ORIGIN OF LEFT CORONARY ARTERY FROM THE LEFT SINUS OF VALSALVA: UNCHARACTERISTIC DEVELOPMENTAL EVENT IN THE TEMPORALLY REGULATED PROCESS. Int J Anat Res 2019;7(2.1):6479-6483.\u00a0DOI:\u00a0<\/strong>10.16965\/ijar.2019.148\u00a0 \n <\/div>\t\n\t\t\n","protected":false},"excerpt":{"rendered":"

    Type of Article:\u00a0\u00a0Case Report Volume 7; Issue 2.1 (April 2019) Page No.:\u00a06479-6483 DOI:\u00a0https:\/\/dx.doi.org\/10.16965\/ijar.2019.148 CLUSTERED ORIGIN OF LEFT CORONARY ARTERY FROM THE LEFT SINUS OF VALSALVA: UNCHARACTERISTIC DEVELOPMENTAL EVENT IN THE TEMPORALLY REGULATED PROCESS Cheryl Melovitz-Vasan 1, Lauren Printz 2, Nagaswami Vasan 3. 1 Associate Professor, Department of Biomedical Sciences, Cooper Medical School of Rowan University,
    + Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages\/1819"}],"collection":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/comments?post=1819"}],"version-history":[{"count":1,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages\/1819\/revisions"}],"predecessor-version":[{"id":1846,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages\/1819\/revisions\/1846"}],"wp:attachment":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/media?parent=1819"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}