{"id":1390,"date":"2018-07-05T14:37:08","date_gmt":"2018-07-05T14:37:08","guid":{"rendered":"http:\/\/www.ijmhr.org\/IntJAnatRes\/?page_id=1390"},"modified":"2018-07-05T14:37:25","modified_gmt":"2018-07-05T14:37:25","slug":"ijar-2018-229","status":"publish","type":"page","link":"https:\/\/www.ijmhr.org\/IntJAnatRes\/ijar-2018-229","title":{"rendered":"IJAR.2018.229"},"content":{"rendered":"
<\/i> DOWNLOAD PDF<\/span><\/a><\/div><\/div><\/div>
<\/i> Table of Contents<\/span><\/a><\/div><\/div><\/div><\/div>\n

Type of Article:<\/strong>\u00a0\u00a0Original Research<\/h3>\n

Volume 6; Issue 3.1 (July 2018)<\/strong><\/h3>\n

Page No.:<\/strong>\u00a05445-5448<\/h3>\n

DOI:\u00a0<\/strong>https:\/\/dx.doi.org\/10.16965\/ijar.2018.229<\/h3>\n

CORPORA AMYLAECIA DEPOSITION IN THE OLFACTORY BULB AND TRACT IN AGEING AND ALZHEIMER\u2019S DISEASE<\/h3>\n

Monali\u00a0 Sonawane 1<\/sup>, Aruna Mukherjee 2<\/sup>, Pravin\u00a0 Rathod *3<\/sup>.<\/strong><\/p>\n

1<\/sup> PhD Scholar\/Associate Professor, Department of Anatomy, M.G.M Institute of Health Sciences, Navi Mumbai, Maharashtra, India.<\/p>\n

2 <\/sup>Professor, Department of Anatomy, M.G.M Medical College, Navi Mumbai, Maharashtra, India.<\/p>\n

*3 <\/sup>PhD Scholar\/Lecturer, Department of Anatomy, M.G.M Institute of Health Sciences, Navi Mumbai, Maharashtra, India.<\/p>\n

Corresponding Author:<\/strong> Pravin Raghunath Rathod, PhD Scholar\/Lecturer, Department of Anatomy, M.G.M Institute of Health Sciences, Navi Mumbai, Maharashtra, India-410209.\u00a0Tel<\/strong> -002227433404 E-Mail: <\/strong>drpravinrathod123@gmail.com<\/p>\n

ABSTRACT<\/h3>\n

Background: <\/strong>\u00a0The olfactory system has several interesting anatomical and physiological features although olfaction has remained a \u2018neglected sense\u2019. Olfactory functioning is a valid indicator of the ageing brain so present study was designed to investigate the age of appearance of corpora amylaecia in the olfactory bulb and tract and compare with well known cases of Alzheimer\u2019s disease.<\/p>\n

Aims of the study: <\/strong>To detect deposition of corpora amylaecia in the human olfactory bulb and tract in different age groups and Alzheimer\u2019s disease.<\/p>\n

Materials and Methods: \u00a0<\/strong>22 brain specimens were collected from cadavers from Anatomy department of MGM Medical College, Navi Mumbai and from National Institute of Mental Health and Sciences (NIMHANS), Bangalore. The study was carried out in 20 undemented specimen, divided into four groups (5 samples in each) according to age: group I (20-39yrs), group II(40-59yrs),group III (60-79yrs),group IV(80 yrs and above) and 2 specimen of Alzheimer\u2019s disease as a control group. Histological evaluation was done with Haematoxylin and Eosin stain, Luxol fast blue stain and Immunohistological stain, Glial fibrillary acidic protein (GFAP) antibody to study corpora amylaecia. Statistical analysis was carried out using Chi Square test.<\/p>\n

Results:<\/strong> In group II, 20%, in Group III and Group IV 80% samples have showed presence of corpora amylaecia. In controls 100% samples had corpora amylaecia. This difference between five groups was statistically significant. In group II, corpora amylaecia was small in size, circular, deeply basophilic and scattered. In group III, IV and V, corpora amylaecia was large in size, more in number and condensed.<\/p>\n

Conclusion: <\/strong>The present study concluded that corpora amylaecia appear as early as fifth decade of life. Corpora amylaecia are age and neurodegeneration related phenomena and their number and size increase with age. Deposition of the corpora amylaecia in the olfactory bulb and tract may be responsible for olfactory dysfunction in advanced age and neurodegenerative disorders<\/p>\n

Key words:<\/strong> Corpora Amylaecia, Olfactory Bulb, Olfactory Tract.<\/p>\n

REFERENCES<\/strong><\/p>\n

    \n
  1. Crossman AR. Special senses. In: Standring S, (edi.) Gray\u2019s anatomy: the anatomical basis of clinical practice. Edinburgh: Elsevier Churchill Livingstone <\/em>2005:431-2.<\/li>\n
  2. Ramsey HJ .Ultrastructure Of Corpora Amylacea. J Neuropathol Exp Neurol 1965;24: 25-39.<\/li>\n
  3. Riberio M, Coutinho L, Mugnol F, Hilbig A, Palmini A, Costa J et al. Corpora amylacea in temporal lobe epilepsy associated with hippocampal sclerosis. Arq Neuropsiquiatr 2003; 61 (4): 942-945.<\/li>\n
  4. Schipper HM, Ciss\u00e9 S. Mitochondrial constituents of corpora amylacea and autofluorescent astrocytic inclusions in senescent human brain. Histol Histopathol 2004; 14 (1): 55-64.<\/li>\n
  5. Singhrao SK, Neal JW, Newman GR.Corpora amylacea could be an indicator of neurodegeneration. Neuropathol Appl Neurobiol 1993;19: 269-276.<\/li>\n
  6. Kovacs,Cairns,Lantos. \u03b2\u2010Amyloid deposition and neurofibrillary tangle formation in the olfactory bulb in ageing and Alzheimer\u2019s disease. Neuropathol Appl Neurobiol 1999; 25(6):481-491.<\/li>\n
  7. Daniel P , Claudiu M. Corpora Amylacea in Aging Brain and Age-Related Brain Disorders. Journal of Aging and Gerontology, 2014; 2(1):33-57.<\/li>\n
  8. Leopold L, Francisco G.The nature of senile changes of the human olfactory bulb and tract.AMA Arch Otolaryngol.\u00a01958; 67(2):167-171.<\/li>\n
  9. Ayesha M, Tahir M. Corpora amylacea in human cadaveric brain age related differences. Biomedica 2008;24:92-95.<\/li>\n<\/ol>\n

    \n\t\t\t

    \n \t Cite this article:<\/strong><\/span> Monali Sonawane, Aruna Mukherjee, Pravin Rathod. CORPORA AMYLAECIA DEPOSITION IN THE OLFACTORY BULB AND TRACT IN AGEING AND ALZHEIMER\u2019S DISEASE. Int J Anat Res 2018;6(3.1):5445-5448.\u00a0DOI:\u00a0<\/strong>10.16965\/ijar.2018.229\u00a0 \n <\/div>\t\n\t\t\n","protected":false},"excerpt":{"rendered":"

    Type of Article:\u00a0\u00a0Original Research Volume 6; Issue 3.1 (July 2018) Page No.:\u00a05445-5448 DOI:\u00a0https:\/\/dx.doi.org\/10.16965\/ijar.2018.229 CORPORA AMYLAECIA DEPOSITION IN THE OLFACTORY BULB AND TRACT IN AGEING AND ALZHEIMER\u2019S DISEASE Monali\u00a0 Sonawane 1, Aruna Mukherjee 2, Pravin\u00a0 Rathod *3. 1 PhD Scholar\/Associate Professor, Department of Anatomy, M.G.M Institute of Health Sciences, Navi Mumbai, Maharashtra, India. 2 Professor, Department
    + Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages\/1390"}],"collection":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/comments?post=1390"}],"version-history":[{"count":1,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages\/1390\/revisions"}],"predecessor-version":[{"id":1408,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages\/1390\/revisions\/1408"}],"wp:attachment":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/media?parent=1390"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}