{"id":1342,"date":"2018-06-05T14:45:58","date_gmt":"2018-06-05T14:45:58","guid":{"rendered":"http:\/\/www.ijmhr.org\/IntJAnatRes\/?page_id=1342"},"modified":"2018-06-05T14:46:30","modified_gmt":"2018-06-05T14:46:30","slug":"ijar-2018-190","status":"publish","type":"page","link":"https:\/\/www.ijmhr.org\/IntJAnatRes\/ijar-2018-190","title":{"rendered":"IJAR.2018.190"},"content":{"rendered":"
<\/i> DOWNLOAD PDF<\/span><\/a><\/div><\/div><\/div>
<\/i> Table of Contents<\/span><\/a><\/div><\/div><\/div><\/div>\n

Type of Article:<\/strong>\u00a0\u00a0Original Research<\/h3>\n

Volume 6; Issue 2.3 (June 2018)<\/strong><\/h3>\n

Page No.:<\/strong>\u00a05294-5300<\/h3>\n

DOI:\u00a0<\/strong>https:\/\/dx.doi.org\/10.16965\/ijar.2018.190<\/h3>\n

FREQUENCY OF ANENCEPHALY AND ITS ASSOCIATED ANOMALIES<\/h3>\n

Shilpa K 1<\/sup>, Priya Ranganath *2<\/sup>, Sumathi S 3<\/sup>.<\/strong><\/p>\n

1<\/sup> Research Scholar, Department of Anatomy, BMCRI, Bangalore, Karnataka, India.<\/p>\n

*2<\/sup> Professor & Head, Department of Anatomy, BMCRI, Bangalore, Karnataka, India.<\/p>\n

3<\/sup> Assistant Professor, Department of Anatomy, BMCRI, Bangalore, Karnataka, India.<\/p>\n

Address for correspondence: <\/strong>Dr. Priya Ranganath, Professor & Head, Department of Anatomy, Bangalore Medical College & Research Institute, Fort, Bangalore \u2013 560002, Karnataka, India.\u00a0E-Mail:<\/strong> priya_ranganath@rediffmail.com<\/p>\n

ABSTRACT:<\/strong><\/p>\n

Introduction: <\/strong>Anencephaly accounts for one of the most common birth defects & is associated with a high mortality & morbidity. The objective was to determine frequency of anencephaly and its associated anomalies, risk factors, clinical presentations & assess maternal awareness on folic acid supplementation and its preventive role in occurrence of anencephaly.<\/p>\n

Materials and Methods:<\/strong> The study includes 60 anencephalic fetuses (23 males & 37 females) of 20-30 weeks. The fetuses were examined for external abnormalities & dissected. \u00a0Measurements of crown heel, crown rump, head circumference, foot length, & weight were taken. All the major organs were weighed & data recorded. The samples were fixed with 10% buffered formaldehyde. The internal anomalies were noted.<\/p>\n

Results:<\/strong> The number of deliveries was 57429 deliveries. 23(38.4%) were males & 37(61.6%) were females. The frequency of anencephaly in 2014 was 15134\/9 (0.06%), in 2015 16361\/21 (0.13%). Weight of 40% were <500gms, 35% were between 500-1000gms & 25% <1000. Maternal age in 83.4% were 21-35 years, in <20 years & >40 years were 1.6% & in 36-40 years were 13.4%.\u00a0 Associated anomalies were present in 42 (70%) fetuses. Out of 42 fetuses, those who had associated anomalies were 17 (40.4%) males and 25 (59.6%) were females. All the fetuses had Acrania (100%) & 19 (45.3%) fetuses had spina bifida; there were no anomalies found in reproductive system.<\/p>\n

Conclusion:<\/strong> 4mg of folic acid should be taken before 6 months of conceiving & during the entire pregnancy. In order to prevent the anencephaly and associated anomalies certain maternal risk factors should be avoided as prescribed by gynecologist.<\/p>\n

KEY WORDS: <\/strong>Anencephaly, Crown Heel, Crown Rump, Head Circumference, Foot Length, Weight.<\/p>\n

REFERENCES<\/strong><\/p>\n

    \n
  1. Tica VI, Beghim M, Zaher M, Beghim E. Anencephaly: pitfalls in pregnancy outcome & relevance of the prenatal exam. Rom J Morphol Embryol.2009;50:295-297.<\/li>\n
  2. Copp AJ, Brooks SA, Estibeiro JP, Shum AS, Cockcroft DL, The embryonic development of mammalian neural tube defects. Prog neurobiol .1990;35:363-403.<\/li>\n
  3. Tonnil G, Azzonil D, Panteghinil M, Ventural A, Cavalli P, First trimester diagnosis of anencephaly associated with fetal malformation & trisomy 18: report of a new cases & gene analysis on folate metabolism in patients. Congenit Anom. 2007;47:101-104.<\/li>\n
  4. Gucciardi E, Pietrusiak MA, Reynolds DL, Rouleau J. Incidence of neural tube defects in Ontario. Canadian Med Assoc J 2002;167:237-240.<\/li>\n
  5. Merker B. Consciousness with a cerebral cortex: A challenge for neuroscience & medicine. Behave Brain Sci .2007;30:63-81.<\/li>\n
  6. Patowary A. The Fourth Incision: A Cosmetic Autopsy Incision Technique. The American journal of forensic medicine and pathology. 2010 Mar 1;31(1):37-41.<\/li>\n
  7. Gupta P, Nain P & Singh J. Anencephaly: A Neural tube defects \u2013A review, American journal of pharmtech research 2016;2(3).<\/li>\n
  8. Kheir AEM, Eisa WMH, Neural tube defects; clinical patterns, Associated risks factors & maternal awareness in Khortoum state Sudan, Journal of medicine & medical research 2015;3(1):1-6.<\/li>\n
  9. Mukhtiar Hassan, Niaz Muhammed, Farzana Gul, Sohail Ahmad, Frequency of Anencephaly in Hazara Division Of Pakistan, American Journal of Drug Delivery & therapeutics 2015;2(1):039-043.<\/li>\n
  10. Golalipour M J, Najafi L, Keshtkar AA. Prevalence of anencephaly in Gorgan, northern Iran. Arch Iran Med. 2010;13:34-7.<\/li>\n
  11. Naik S, Venkataramanababu P, Study of various congenital anomalies in fetal & neonatal autopsies, International Journal of Research in medical sciences May 2015;3(5):1114-1117.<\/li>\n
  12. Tan KC, Ratham SS, Kottegoda SR, Anencephaly: A retrospective analysis, Singapore 1976 to 1980 J of Med Genetics 1984;21;350-354.<\/li>\n
  13. Vare AM, Bansal PC. Anencephaly: An Anatomical study of 41 anencephalies Indian journal Pediatric 1971;38:301-305.<\/li>\n
  14. Neilson LAG, Maroun LL, Graem N, Neural tube defects & associated anomalies in a fetal &perinatal autopsy series,Acta patho Microbial Immunol scand 2006;114:239-246.<\/li>\n
  15. Panduranga C, Kangle R, Suranagi V, Pilli GS, Anencephaly: A pathological study of 41 cases J sci soc 2012;39:81-84.<\/li>\n
  16. Singh J, Kapoor K, Kochhar S. Incidence of Anencephaly in a tertiary care hospital in North west India International journal of scientific & research publications 2015;5(9):2230-315.<\/li>\n
  17. Czeizel A, Schisis- association. Am J Med Genet 1981;10:25-35.<\/li>\n
  18. Kutuk MS, Ozgun MT, Uludag S et al. A case of dichorionic twin pregnancy concordant for bilateral cleft lip 7 palate & discordant for spinabifida; Schisis association. Fetal pediatr pathol 2013;32:371-4.<\/li>\n
  19. Kulkarni M L, Gopal PV, Amniotic band syndrome, Indian Pediatric 1990;27:471-6.<\/li>\n
  20. Chen H, Gonzalez E, Amniotic band sequence & its neurocutaneous manifestations. Am J Med Genet 1987;28:661-73.<\/li>\n
  21. Miller ME, Graham Jr JM, Higginbottom MC, Smith DW. Compression- related defects from early amnion rupture; evidence for mechanical teratogenesis. J Pediatric 1981;98:292-7.<\/li>\n
  22. Potter\u2019s pathology of the fetus, infant and child. vol 1 & 2, second edition, Elsevier<\/li>\n
  23. Gupta P, Nain P & Singh J. Anencephaly:A Neural tube defects \u2013A review, American journal of pharmtech research, 2016;2(3).<\/li>\n
  24. Moore L, Anencephaly, Journal of Diagnostic Medical Sonography 2010;26(6):286-289.<\/li>\n<\/ol>\n

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    \n \t Cite this article:<\/strong><\/span> Shilpa K, Priya Ranganath, Sumathi S. FREQUENCY OF ANENCEPHALY AND ITS ASSOCIATED ANOMALIES. Int J Anat Res 2018;6(2.3):5294-5300.\u00a0DOI:\u00a0<\/strong>10.16965\/ijar.2018.190\u00a0 \n <\/div>\t\n\t\t\n","protected":false},"excerpt":{"rendered":"

    Type of Article:\u00a0\u00a0Original Research Volume 6; Issue 2.3 (June 2018) Page No.:\u00a05294-5300 DOI:\u00a0https:\/\/dx.doi.org\/10.16965\/ijar.2018.190 FREQUENCY OF ANENCEPHALY AND ITS ASSOCIATED ANOMALIES Shilpa K 1, Priya Ranganath *2, Sumathi S 3. 1 Research Scholar, Department of Anatomy, BMCRI, Bangalore, Karnataka, India. *2 Professor & Head, Department of Anatomy, BMCRI, Bangalore, Karnataka, India. 3 Assistant Professor, Department of
    + Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages\/1342"}],"collection":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/comments?post=1342"}],"version-history":[{"count":1,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages\/1342\/revisions"}],"predecessor-version":[{"id":1346,"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/pages\/1342\/revisions\/1346"}],"wp:attachment":[{"href":"https:\/\/www.ijmhr.org\/IntJAnatRes\/wp-json\/wp\/v2\/media?parent=1342"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}